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Details on Person UniProt:P08122 Col4a2
| Class:Id | ReferenceGeneProduct:86367 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Sat February 7 2015;propeptide:26-183 added on Sat February 7 2015;chain:184-1707 added on Sat February 7 2015;chain:1481-1707 added on Sat February 7 2015 |
| _displayName | UniProt:P08122 Col4a2 |
| _timestamp | 2023-11-03 17:22:23 |
| chain | signal peptide:1-25 propeptide:26-183 chain:184-1707 chain:1481-1707 |
| checksum | 67CB3E3CB2A5B1F6 |
| comment | FUNCTION Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.FUNCTION Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity).SUBUNIT There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. Interacts with EFEMP2 (PubMed:17324935).SUBCELLULAR LOCATION Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.PTM Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.PTM Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.PTM Proteolytic processing produces the C-terminal NC1 peptide, canstatin.PTM The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.PTM Brominated by PXDN.SIMILARITY Belongs to the type IV collagen family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence starting in position 277.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence starting in position 277. |
| description | recommendedName: fullName evidence="8"Collagen alpha-2(IV) chain component recommendedName: Canstatin /component |
| geneName | Col4a2 |
| identifier | P08122 |
| isSequenceChanged | FALSE |
| keyword | Angiogenesis Basement membrane Bromination Collagen Disulfide bond Extracellular matrix Glycoprotein Hydroxylation Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Col4a2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CO4A2_MOUSE Q3B7C2 Q3TPV9 Q61375 Q66JS5 Q6RCT6 Q6RCT7 Q6U9X1 Q8BPI9 Q8BPK3 Q91VI3 |
| sequenceLength | 1707 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:2447194] Col4a2 [extracellular region] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P08122 Col4a2 (86367)
