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Details on Person UniProt:P15530 Cd79b
| Class:Id | ReferenceGeneProduct:86331 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-228 added on Fri February 6 2015 |
| _displayName | UniProt:P15530 Cd79b |
| _timestamp | 2024-11-03 19:44:59 |
| chain | signal peptide:1-25 chain:26-228 |
| checksum | 9A3A2008648E8307 |
| comment | FUNCTION Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.SUBUNIT Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN.INTERACTION Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.TISSUE SPECIFICITY B-cells.DOMAIN The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes.PTM Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| description | recommendedName: B-cell antigen receptor complex-associated protein beta chain alternativeName: B-cell-specific glycoprotein B29 alternativeName: Ig-beta alternativeName: Immunoglobulin-associated B29 protein cdAntigenNameCD79b/cdAntigenName |
| geneName | Cd79b Igb |
| identifier | P15530 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Adaptive immunity Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Phosphoprotein Receptor Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | Cd79b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CD79B_MOUSE Q4FJP4 |
| sequenceLength | 228 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1112652] p-Y195,206-Cd79b [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:1112654] Cd79b (Ig-beta) [plasma membrane] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:1112643] O4'-phospho-L-tyrosine at 195 [ModifiedResidue:1112651] O4'-phospho-L-tyrosine at 206 |
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No pathways have been reviewed or authored by UniProt:P15530 Cd79b (86331)
