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Details on Person UniProt:Q9Y5K6 CD2AP
| Class:Id | ReferenceGeneProduct:86219 |
|---|---|
| _chainChangeLog | chain:1-639 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y5K6 CD2AP |
| _timestamp | 2026-02-20 22:52:44 |
| chain | chain:1-639 |
| checksum | 7576509C7ED5B343 |
| comment | FUNCTION Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (PubMed:10339567). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell (By similarity). May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis (PubMed:15800069). Plays a role in epithelial cell junctions formation (PubMed:22891260).SUBUNIT Homodimer. Interacts with F-actin, PKD2, NPHS1 and NPHS2. Interacts with WTIP. Interacts with DDN; interaction is direct. Interacts (via SH3 2 domain) with CBL (via phosphorylated C-terminus). Interacts with BCAR1/p130Cas (via SH3 domain). Interacts with MVB12A and ARHGAP17. Interacts with ANLN, CD2 and CBLB. Interacts with PDCD6IP and TSG101. Interacts with RIN3. Interacts directly with RET (inactive) and CBLC; upon RET activation by GDNF suggested to dissociate from RET as CBLC:CD2AP complex (Probable) (PubMed:10339567, PubMed:11067845, PubMed:15800069, PubMed:16678097, PubMed:16895919, PubMed:17020880, PubMed:17853893, PubMed:18753381, Ref.30). Interacts with CGNL1 and SH3BP1; probably part of a complex at cell junctions (PubMed:22891260). Interacts with CAPZA1 (PubMed:22891260).SUBUNIT (Microbial infection) Interacts (via SH3 domains) with Chikungunya virus non-structural protein 3 (via C-terminus); this interaction plays a role in initiation of viral replication.SUBCELLULAR LOCATION Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles (PubMed:10339567). Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase (PubMed:15800069).TISSUE SPECIFICITY Widely expressed in fetal and adult tissues.DOMAIN The Pro-rich domain may mediate binding to SH3 domains.DOMAIN Potential homodimerization is mediated by the coiled coil domain.PTM Phosphorylated on tyrosine residues; probably by c-Abl, Fyn and c-Src.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. |
| description | recommendedName: CD2-associated protein alternativeName: Adapter protein CMS alternativeName: Cas ligand with multiple SH3 domains |
| geneName | CD2AP |
| identifier | Q9Y5K6 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Cell junction Cell projection Coiled coil Cytoplasm Cytoskeleton Host-virus interaction Isopeptide bond Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat SH3 domain SH3-binding Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | CD2AP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994704] ENSEMBL:ENSG00000198087 CD2AP [Homo sapiens] |
| secondaryIdentifier | CD2AP_HUMAN A6NL34 Q5VYA3 Q9UG97 |
| sequenceLength | 639 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:373620] CD2AP [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y5K6 CD2AP (86219)
