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Details on Person UniProt:Q96IU4 ABHD14B
| Class:Id | ReferenceGeneProduct:86200 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-210 added on Fri February 6 2015;initiator methionine:1 for 86200 removed on Fri Nov 03 2023;initiator methionine: for 86200 added on Fri Nov 03 2023;initiator methionine: for 86200 removed on Fri Aug 15 2025;initiator methionine:1 for 86200 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q96IU4 ABHD14B |
| _timestamp | 2025-08-15 21:35:45 |
| chain | initiator methionine:1 chain:2-210 |
| checksum | 3CACE8759A2ADFAD |
| comment | FUNCTION Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo (Probable). Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate (PubMed:14672934, PubMed:31478652). May activate transcription (PubMed:14672934).CATALYTIC ACTIVITY L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 2.2 min(-1) for p-nitrophenyl-acetate (PubMed:31478652). kcat is 0.6 min(-1) for p-nitrophenyl-butyrate (PubMed:31478652). kcat is 0.2 min(-1) for p-nitrophenyl-octanoate (PubMed:31478652).SUBUNIT May interact with TAF1.SUBCELLULAR LOCATION Predominantly cytoplasmic.ALTERNATIVE PRODUCTS Ubiquitous (PubMed:14672934). Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney (PubMed:14672934).SIMILARITY Belongs to the AB hydrolase superfamily. ABHD14 family.CAUTION The protein-lysine deacetylase activity using CoA as substrate is unclear as this protein belongs to a family of serine hydrolases, and that the reaction shown in the publication is not hydrolyzing H(2)O. Additional experiments are therefore required to confirm this activity in vivo. |
| description | recommendedName: fullName evidence="7"Putative protein-lysine deacylase ABHD14B ecNumber evidence="9"2.3.1.- alternativeName: fullName evidence="7"Alpha/beta hydrolase domain-containing protein 14B shortName evidence="10"Abhydrolase domain-containing protein 14B alternativeName: fullName evidence="4"CCG1-interacting factor B |
| geneName | ABHD14B CIB |
| identifier | Q96IU4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Acyltransferase Alternative splicing Cytoplasm Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ABHD14B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989350] ENSEMBL:ENSG00000114779 ABHD14B [Homo sapiens] |
| secondaryIdentifier | ABHEB_HUMAN Q86VK8 Q8N8W5 |
| sequenceLength | 210 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144780] UniProt:Q96IU4-2 ABHD14B [Homo sapiens] [ReferenceIsoform:412829] UniProt:Q96IU4-1 ABHD14B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5695994] ABHD14B [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96IU4 ABHD14B (86200)
