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Details on Person UniProt:O70552 Btg4
Class:Id
ReferenceGeneProduct:86134
_chainChangeLog
chain:1-250 added on Fri February 6 2015
_displayName
UniProt:O70552 Btg4
_timestamp
2023-11-03 15:25:18
chain
chain:1-250
checksum
9C175309C017F7BD
comment
FUNCTION Adapter protein that bridges CNOT7, a catalytic subunit of the CCR4-NOT complex, to EIF4E, and facilitates maternal mRNAs decay during the maturation of oocytes and in the fertilized egg (PubMed:27065194). It is therefore required for the maternal-zygotic transition (MZT), zygotic cleavage and initiation of embryonic development (PubMed:27065194).SUBUNIT Interacts with CNOT7 and EIF4E (PubMed:27065194). Interacts with CNOT8 (PubMed:27065194).INTERACTION Expressed in oocytes (PubMed:27065194). Expressed in testis and in olfactory epithelium.DISRUPTION PHENOTYPE BTG4-null mice are viable, have body sizes similar to those of their wild type littermates, are healthy up to 1 year of age, and do not spontaneously develop tumors. Females are sterile and their embryos are arrested at the one- or two-cells stage.SIMILARITY Belongs to the BTG family.
description
recommendedName: Protein BTG4 alternativeName: BTG family member 4 alternativeName: Protein PC3b
