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Details on Person UniProt:O35185 Bhlhe40
| Class:Id | ReferenceGeneProduct:85947 |
|---|---|
| _chainChangeLog | chain:1-411 added on Fri February 6 2015 |
| _displayName | UniProt:O35185 Bhlhe40 |
| _timestamp | 2023-11-03 15:25:13 |
| chain | chain:1-411 |
| checksum | B392893CD49292BC |
| comment | FUNCTION Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes (PubMed:18411297). Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop) (PubMed:14672706). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (By similarity). Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1|BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes (By similarity). Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2 (PubMed:14672706). Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity (PubMed:19786558). May function as a transcriptional factor for neuronal differentiation (PubMed:9284045). Represses the transcription of NR0B2 and attentuates the transactivation of NR0B2 by the CLOCK-BMAL1 complex (By similarity). Drives the circadian rhythm of blood pressure through transcriptional repression of ATP1B1 in the cardiovascular system (PubMed:30012868).SUBUNIT Homodimer. Heterodimer with BHLHE41/DEC2. Interacts with ubiquitin-conjugating enzyme UBE2I/UBC9. Interacts with HDAC1, SUMO1, RXRA and BMAL1 (By similarity). Interacts with TCF3/E47.SUBCELLULAR LOCATION Predominantly localized in the nucleus (By similarity).DEVELOPMENTAL STAGE Expressed from 9.5 dpc to 17.5 dpc in the ventricular layer of the brain and spinal cord, but also in the retinal pigment epithelium, developing eyelids, nasal epithelium, serous gland, vibrissae, epithelium of the mouth cavity and the tooth buds. Highly expressed in the heart, thymus and adrenal glands followed by lung, liver parenchyma, kidney tubules, epithelium of the esophagus and stomach. From 15.5 dpc to 17.5 dpc it is expressed in urinary bladder and urethra. From 17.5 dpc, it is expressed in developing muscle.INDUCTION Stimulated by retinoic acid (RA). Expressed in a circadian manner in the liver with a peak at ZT10.PTM Ubiquitinated; which may lead to proteasomal degradation.PTM Sumoylation inhibits its ubiquitination and promotes its negative regulation of the CLOCK-BMAL1 heterodimer transcriptional activator activity. |
| description | recommendedName: Class E basic helix-loop-helix protein 40 shortName: bHLHe40 alternativeName: Class B basic helix-loop-helix protein 2 shortName: bHLHb2 alternativeName: fullName evidence="12"Differentially expressed in chondrocytes protein 1 shortName evidence="12"DEC1 alternativeName: E47 interaction protein 1 shortName: EIP1 alternativeName: Stimulated by retinoic acid gene 13 protein |
| geneName | Bhlhe40 Bhlhb2 Clast5 Dec1 Stra13 |
| identifier | O35185 |
| isSequenceChanged | FALSE |
| keyword | Biological rhythms Cytoplasm DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Bhlhe40 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BHE40_MOUSE P97289 |
| sequenceLength | 411 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:879743] Bhlhe40 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O35185 Bhlhe40 (85947)
