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Details on Person UniProt:P59998 ARPC4
| Class:Id | ReferenceGeneProduct:85219 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-168 added on Fri February 6 2015;initiator methionine:1 for 85219 removed on Fri Nov 03 2023;initiator methionine: for 85219 added on Fri Nov 03 2023;initiator methionine: for 85219 removed on Fri Aug 15 2025;initiator methionine:1 for 85219 added on Fri Aug 15 2025 |
| _displayName | UniProt:P59998 ARPC4 |
| _timestamp | 2025-08-15 21:51:10 |
| chain | initiator methionine:1 chain:2-168 |
| checksum | 273CCB230AC703DF |
| comment | FUNCTION Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the ARPC4 family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Actin-related protein 2/3 complex subunit 4 alternativeName: Arp2/3 complex 20 kDa subunit shortName: p20-ARC |
| geneName | ARPC4 ARC20 |
| identifier | P59998 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Intellectual disability Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ARPC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997021] ENSEMBL:ENSG00000241553 ARPC4 [Homo sapiens] |
| secondaryIdentifier | ARPC4_HUMAN C9JWM7 E7ETI0 F6TTL5 O15509 Q6P0W5 Q96QJ3 |
| sequenceLength | 168 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8972288] UniProt:P59998-1 ARPC4 [Homo sapiens] [ReferenceIsoform:8972289] UniProt:P59998-2 ARPC4 [Homo sapiens] [ReferenceIsoform:8972290] UniProt:P59998-3 ARPC4 [Homo sapiens] [ReferenceIsoform:8972291] UniProt:P59998-4 ARPC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:200813] ARPC4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:202988] ARPC4 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P59998 ARPC4 (85219)
