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Details on Person UniProt:Q9UJX5 ANAPC4
| Class:Id | ReferenceGeneProduct:84978 |
|---|---|
| _chainChangeLog | chain:1-808 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UJX5 ANAPC4 |
| _timestamp | 2024-11-03 19:44:38 |
| chain | chain:1-808 |
| checksum | 80362CC8D8B2063F |
| comment | FUNCTION Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).PATHWAY Protein modification; protein ubiquitination.SUBUNIT The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:25043029, PubMed:26083744, PubMed:27259151, PubMed:9469815). In the context of the APC/C complex, directly interacts with UBE2S (PubMed:27259151). Interacts with FBXO43.INTERACTION Belongs to the APC4 family. |
| description | recommendedName: Anaphase-promoting complex subunit 4 shortName: APC4 alternativeName: Cyclosome subunit 4 |
| geneName | ANAPC4 APC4 |
| identifier | Q9UJX5 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Isopeptide bond Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ANAPC4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002200] ENSEMBL:ENSG00000053900 ANAPC4 [Homo sapiens] |
| secondaryIdentifier | APC4_HUMAN A8K8H1 E9PCR4 Q6PCC6 Q9NSH6 |
| sequenceLength | 808 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:144021] UniProt:Q9UJX5-2 ANAPC4 [Homo sapiens] [ReferenceIsoform:415430] UniProt:Q9UJX5-1 ANAPC4 [Homo sapiens] [ReferenceIsoform:8971788] UniProt:Q9UJX5-3 ANAPC4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174115] ANAPC4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:174168] ANAPC4 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UJX5 ANAPC4 (84978)
