Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9H1A4 ANAPC1
| Class:Id | ReferenceGeneProduct:84973 |
|---|---|
| _chainChangeLog | chain:1-1944 added on Sat February 7 2015 |
| _displayName | UniProt:Q9H1A4 ANAPC1 |
| _timestamp | 2024-11-03 19:55:09 |
| chain | chain:1-1944 |
| checksum | E08B1FE3FC28917E |
| comment | FUNCTION Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).PATHWAY Protein modification; protein ubiquitination.SUBUNIT The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.PTM Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the APC1 family. |
| description | recommendedName: Anaphase-promoting complex subunit 1 shortName: APC1 alternativeName: Cyclosome subunit 1 alternativeName: Mitotic checkpoint regulator alternativeName: Testis-specific gene 24 protein |
| geneName | ANAPC1 TSG24 |
| identifier | Q9H1A4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Dwarfism Ectodermal dysplasia Hypotrichosis Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | ANAPC1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995277] ENSEMBL:ENSG00000153107 ANAPC1 [Homo sapiens] |
| secondaryIdentifier | APC1_HUMAN Q2M3H8 Q9BSE6 Q9H8D0 |
| sequenceLength | 1944 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:174189] ANAPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174217] ANAPC1 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9H1A4 ANAPC1 (84973)
