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Details on Person UniProt:P24587 Akap5
| Class:Id | ReferenceGeneProduct:84791 |
|---|---|
| _chainChangeLog | chain:1-714 added on Fri February 6 2015 |
| _displayName | UniProt:P24587 Akap5 |
| _timestamp | 2024-11-03 19:39:55 |
| chain | chain:1-714 |
| checksum | 933ED7E0CD236AEA |
| comment | FUNCTION Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (By similarity). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (By similarity). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses.SUBUNIT Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts (By similarity). Interacts with ORAI1 (isoform alpha) (via N-terminus) upon store depletion and in response to LTC4. Does not interact with ORAI2 and ORAI3 paralogs. Interacts (via leucine zipper domain) with NFATC2/NFAT1 (By similarity). Interacts with calmodulin; the interaction is calcium-independent (By similarity). Interacts with KCNQ2; the interaction may help KCNQ2 channel complex to retain calcium-bound calmodulin (PubMed:24349250). Interacts with KCNK2; the channel is recruited to postsynaptic microdomains by AKAP5 where it can integrate neurotransmitter receptor signals. Part of a complex composed of AKAP5 and ADRB2.SUBCELLULAR LOCATION Associates with lipid rafts.DOMAIN RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.DOMAIN The N-terminal region, which is highly basic, is required for interaction with calmodulin.PTM Palmitoylated. Palmitoylation at Cys-36 and Cys-123 plays a key role in the targeting of AKAP5 to lipid rafts. Palmitoylation by ZDHHC2 is required for AKAP5 function in LTP-stimulated recycling endosome exocytosis. |
| description | recommendedName: A-kinase anchor protein 5 shortName: AKAP-5 alternativeName: A-kinase anchor protein 150 kDa shortName: AKAP 150 shortName: P150 alternativeName: cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein |
| geneName | Akap5 Akap150 |
| identifier | P24587 |
| isSequenceChanged | FALSE |
| keyword | Calmodulin-binding Cell membrane Cell projection Endosome Lipoprotein Membrane Palmitate Phosphoprotein Postsynaptic cell membrane Reference proteome Repeat Synapse |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | Akap5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | AKAP5_RAT P70593 |
| sequenceLength | 714 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:446984] A-kinase anchor protein 5 [plasma membrane] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:P24587 Akap5 (84791)
