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Details on Person Phosphorylated TAK1 dissociates from the TLR3 receptor complex

Class:Id	Reaction:847070
_displayName	Phosphorylated TAK1 dissociates from the TLR3 receptor complex
_doRelease	TRUE
_timestamp	2017-12-01 23:35:11
authored	[InstanceEdit:765399] Shamovsky, V, 2010-05-21
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:847072] Shamovsky, V, 2010-05-28
edited	[InstanceEdit:765399] Shamovsky, V, 2010-05-21
input	[Complex:177691] viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:177899] Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR [LiteratureReference:169927] Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
modified	[InstanceEdit:868604] Garapati, P V, 2010-06-02 [InstanceEdit:2457719] Shamovsky, V, 2012-08-28 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8979781] Shamovsky, Veronica, 2017-02-27 [InstanceEdit:9014336] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated TAK1 dissociates from the TLR3 receptor complex
output	[Complex:168907] viral dsRNA:TLR3:TICAM1 [endosome membrane] [Homo sapiens] [Complex:847073] K63pUb-TRAF6:TAB1:TAB2,TAB3:free pUb:p-T-TAK1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:177692] Activation of recruited TAK1 within the activated TLR3 complex [Homo sapiens] [Reaction:177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex [Homo sapiens]
relatedSpecies	[Species:5229092] Hepatitis B virus [Species:5621375] Hepatitis C Virus [Species:5689680] Human herpesvirus 1 [Species:5617433] Rotavirus [Species:9031716] Influenza A virus
releaseDate	2010-12-14
reviewed	[InstanceEdit:844686] Gillespie, ME, 2010-05-28 [InstanceEdit:2582977] Fitzgerald, Katherine A, 2012-11-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8927664] R-HSA-847070.3
summation	[Summation:847071] Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leav...
(hasEvent)	[Pathway:9014325] TICAM1,TRAF6-dependent induction of TAK1 complex [Homo sapiens]
(inferredFrom)	[Reaction:921145] Activated chicken TAK1 dissociates from the activated TLR3 complex [Gallus gallus]
(precedingEvent)	[Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:450337] Activated TAK1 phosphorylates MKK4/MKK7 [Homo sapiens] [Reaction:450346] activated human TAK1 phosphorylates MKK3/MKK6 [Homo sapiens] [Reaction:9757952] Activated TAK1 phosphorylates IKBKB [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790046] Update Tracker - [Reaction:847070] Phosphorylated TAK1 dissociates from the TLR3 receptor complex - v35:[modifyText]
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