Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person In the absence of TLR agonist 'priming', inflammasome depend...
| Class:Id | Summation:844632 |
|---|---|
| _displayName | In the absence of TLR agonist 'priming', inflammasome depend... |
| _timestamp | 2010-05-28 17:09:19 |
| created | [InstanceEdit:844626] Jupe, S, 2010-05-28 |
| literatureReference | [LiteratureReference:844628] Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression |
| modified | [InstanceEdit:844647] Jupe, S, 2010-05-28 |
| text | In the absence of TLR agonist 'priming', inflammasome dependent caspase-1 activation is observed but IL-1 beta secretion is minimal because pro-IL1 beta is not expressed in most cells until stimulated by proinflammatory signals such as TNF or LPS that activate NFkappaB. NFkappaB induces expression of pro-IL1beta but also expression of NLRP3 which may be a limiting component of the NLRP3 inflammasome complex. |
| (summation) | [Reaction:448703] Interleukin-1 family precursors are cleaved by caspase-1 [Homo sapiens] |
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No pathways have been reviewed or authored by In the absence of TLR agonist 'priming', inflammasome depend... (844632)
