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Details on Person NLRP1 binds procaspase-1

Class:Id	Reaction:844608
_displayName	NLRP1 binds procaspase-1
_doRelease	FALSE
_timestamp	2016-07-15 23:49:39
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:844609] Jupe, S, 2010-05-28
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[Polymer:1296412] MDP:NLRP1:ATP oligomer [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:448692] CASP1(1-404) [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:844454] Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
modified	[InstanceEdit:844626] Jupe, S, 2010-05-28 [InstanceEdit:877366] Jupe, S, 2010-06-14 [InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1254262] Jupe, S, 2011-04-28 [InstanceEdit:1296413] Jupe, S, 2011-05-20 [InstanceEdit:1361857] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:3465600] Shamovsky, V, 2013-05-17 [InstanceEdit:3632904] Jupe, S, 2013-05-28 [InstanceEdit:8879177] Wu, G, 2016-07-15
name	NLRP1 binds procaspase-1
output	[Complex:877371] MDP:NLRP1:ATP Oligomer:Procaspase-1 [cytosol] [Homo sapiens]
precedingEvent	[Polymerisation:844438] NLRP1 oligomerizes [Homo sapiens] [Reaction:879222] MDP:NLRP1 binds ATP [Homo sapiens]
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8900486] R-HSA-844608.1
summation	[Summation:877356] The C-teminal CARD domain of NLRP1 is able to bind procaspas...
(hasEvent)	[Pathway:844455] The NLRP1 inflammasome [Homo sapiens]
(precedingEvent)	[Reaction:448678] CTSG cleaves CASP1(1-404) [Homo sapiens]
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No pathways have been reviewed or authored by NLRP1 binds procaspase-1 (844608)