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Details on Person NLRP3 activation by elicitor proteins

Class:Id	BlackBoxEvent:844440
_displayName	NLRP3 activation by elicitor proteins
_doRelease	TRUE
_timestamp	2018-02-26 18:35:46
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:844451] Jupe, S, 2010-05-28
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[Complex:874086] NLRP3:SUGT1:HSP90 [cytosol] [Homo sapiens] [DefinedSet:9038383] NLRP3 elicitor proteins [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:844443] The inflammasomes
modified	[InstanceEdit:844509] Jupe, S, 2010-05-28 [InstanceEdit:844609] Jupe, S, 2010-05-28 [InstanceEdit:874056] Jupe, S, 2010-06-09 [InstanceEdit:874110] Jupe, S, 2010-06-10 [InstanceEdit:877211] Jupe, S, 2010-06-11 [InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1250252] Jupe, S, 2011-04-15 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1306877] Jupe, S, 2011-05-27 [InstanceEdit:1306881] Jupe, S, 2011-05-27 [InstanceEdit:1317415] D'Eustachio, P, 2011-06-01 [InstanceEdit:1361857] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:5621491] Matthews, Lisa, 2014-08-29 [InstanceEdit:9038382] D'Eustachio, Peter, 2018-02-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NLRP3 activation by elicitor proteins
output	[Complex:1306879] NLRP3 elicitor proteins:NLRP3 [cytosol] [Homo sapiens] [Complex:874112] SUGT1:HSP90 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:877187] P2X7 mediates loss of intracellular K+ [Homo sapiens] [Reaction:877158] P2X7 forms oligomeric non-selective cation channels [Homo sapiens] [BlackBoxEvent:877198] P2X7 mediates membrane pores that include pannexin-1 [Homo sapiens] [Reaction:877158] P2X7 forms oligomeric non-selective cation channels [Homo sapiens] [Reaction:873951] SGT1:HSP90 binds inactive NLRP3 [Homo sapiens] [Reaction:874087] SGT1 binds HSP90 [Homo sapiens] [Reaction:1250272] TXNIP binds NLRP3 [Homo sapiens] [Reaction:1250264] TXNIP binds reduced thioredoxin [Homo sapiens] [BlackBoxEvent:9603905] Expression of NLRP3 gene [Homo sapiens] [BlackBoxEvent:877173] Syk couples sensing of fungal pathogens to NLRP3 inflammasome [Homo sapiens]
relatedSpecies	[Species:877180] Staphylococcus aureus
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357609] R-HSA-844440.3
summation	[Summation:844607] The NLRP3 inflammasome is activated by a range of stimuli of...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens]
(precedingEvent)	[Polymerisation:1296421] NLRP3 oligomerizes via NACHT domains [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779770] Update Tracker - [BlackBoxEvent:844440] NLRP3 activation by elicitor proteins - v64:[add_removeInput]
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No pathways have been reviewed or authored by NLRP3 activation by elicitor proteins (844440)