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Details on Person UniProt:Q9NUB1 ACSS1
| Class:Id | ReferenceGeneProduct:84405 |
|---|---|
| _chainChangeLog | transit peptide:1-37 added on Fri February 6 2015;chain:38-689 added on Fri February 6 2015 |
| _displayName | UniProt:Q9NUB1 ACSS1 |
| _timestamp | 2025-02-21 19:24:53 |
| chain | transit peptide:1-37 chain:38-689 |
| checksum | 66E84E39302AD08B |
| comment | FUNCTION Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity).CATALYTIC ACTIVITY acetate + ATP + CoA = acetyl-CoA + AMP + diphosphateCATALYTIC ACTIVITY propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphateACTIVITY REGULATION Inhibited by acetylation at Lys-642 and activated by deacetylation mediated by the deacetylase SIRT3.SUBUNIT Interacts with SIRT3.INTERACTION Reversibly acetylated on Lys-642 (PubMed:16788062). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3.SIMILARITY Belongs to the ATP-dependent AMP-binding enzyme family.SEQUENCE CAUTION Sequencing errors. |
| description | recommendedName: Acetyl-coenzyme A synthetase 2-like, mitochondrial ecNumber evidence="6"6.2.1.1 alternativeName: Acetate--CoA ligase 2 alternativeName: fullName evidence="10"Acetyl-CoA synthetase 2 shortName evidence="10"AceCS2 alternativeName: Acyl-CoA synthetase short-chain family member 1 alternativeName: Propionate--CoA ligase ecNumber evidence="2"6.2.1.17 |
| geneName | ACSS1 ACAS2L KIAA1846 |
| identifier | Q9NUB1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Direct protein sequencing Ligase Lipid metabolism Mitochondrion Nucleotide-binding Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ACSS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988253] ENSEMBL:ENSG00000154930 ACSS1 [Homo sapiens] |
| secondaryIdentifier | ACS2L_HUMAN B3KXL2 B4DJZ3 D3DW48 F5H6F4 F8W7Y1 Q5TF42 Q8IV99 Q8N234 Q96JI1 Q96JX6 Q9NU28 |
| sequenceLength | 689 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:143774] UniProt:Q9NUB1-2 ACSS1 [Homo sapiens] [ReferenceIsoform:414795] UniProt:Q9NUB1-1 ACSS1 [Homo sapiens] [ReferenceIsoform:8977277] UniProt:Q9NUB1-3 ACSS1 [Homo sapiens] [ReferenceIsoform:8977278] UniProt:Q9NUB1-4 ACSS1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:449914] ACSS1 [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NUB1 ACSS1 (84405)
