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Details on Person UniProt:Q8TF62 ATP8B4
| Class:Id | ReferenceGeneProduct:84316 |
|---|---|
| _chainChangeLog | chain:1-1192 added on Fri February 6 2015 |
| _displayName | UniProt:Q8TF62 ATP8B4 |
| _timestamp | 2025-05-21 21:03:59 |
| chain | chain:1-1192 |
| checksum | FFE8D935B7544D73 |
| comment | FUNCTION Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable).CATALYTIC ACTIVITY ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.COFACTOR Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunits TMEM30A and TMEM30B.INTERACTION Ubiquitously expressed at moderate levels.SIMILARITY Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.SEQUENCE CAUTION Contaminating sequence. Sequence of unknown origin inserted in the coding sequence. |
| description | recommendedName: Probable phospholipid-transporting ATPase IM ecNumber: 7.6.2.1 alternativeName: ATPase class I type 8B member 4 alternativeName: P4-ATPase flippase complex alpha subunit ATP8B4 |
| geneName | ATP8B4 KIAA1939 |
| identifier | Q8TF62 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell membrane Golgi apparatus Lipid transport Magnesium Membrane Metal-binding Nucleotide-binding Proteomics identification Reference proteome Translocase Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | ATP8B4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992314] ENSEMBL:ENSG00000104043 ATP8B4 [Homo sapiens] |
| secondaryIdentifier | AT8B4_HUMAN Q9H727 |
| sequenceLength | 1192 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:939737] ATP8B4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799519] ATP8B4 [specific granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6800924] ATP8B4 [tertiary granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8TF62 ATP8B4 (84316)
