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Details on Person UniProt:P05623 SP
| Class:Id | ReferenceGeneProduct:84309 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-55 added on Fri February 6 2015 |
| _displayName | UniProt:P05623 SP |
| _timestamp | 2026-05-15 20:18:33 |
| chain | signal peptide:1-19 chain:20-55 |
| checksum | F6827A1F1BBC6C5D |
| comment | FUNCTION Male seminal protein which triggers short- and long-term post-mating behavioral responses (PMR) in female Drosophila (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:20308537, PubMed:24089336, PubMed:3135120). Binds initially to sperm where it is later cleaved to release an active peptide within the female reproductive tract. Signals via the sex peptide receptor (SPR) in female flies; may also act via other receptors (PubMed:20308537, PubMed:20458515, PubMed:24089336). Moderates the activity of distinct neuronal circuitries in the female genital tract to promote specific PMRs including: enhanced ovulation, increased egg laying rate, increased feeding/foraging rate, induced antimicrobial peptide synthesis, reduced mating receptivity, reduced day-time sleep and reduced lifespan in multiple mated females (PubMed:15694303, PubMed:19249273, PubMed:19793753, PubMed:24089336, PubMed:3135120). Structural component of large neutral lipid-containing microcarriers produced by male accessory gland main cells; involved in their morphogenesis and their role in delivering lipids and lipid associated proteins to females during mating (PubMed:33495334).SUBCELLULAR LOCATION Surface component of large neutral lipid-containing microcarriers produced by male accessory gland main cells and secreted into seminal fluid (PubMed:33495334). Microcarriers disassembl in females after delivery by mating, and components including some SP protein associate with tails of stored sperm (PubMed:33495334).TISSUE SPECIFICITY Main cells of the accessory glands of males (paragonial gland).DEVELOPMENTAL STAGE No expression in females or embryos (PubMed:20458515, PubMed:3135120). Expression levels are highest in male adults with little to no expression until the late pupal stages (PubMed:20458515, PubMed:3135120).DOMAIN The N-terminal domain is important for microcarrier assembly as well as sperm binding.PTM Sperm-bound protein is cleaved to release an active C-terminal peptide. Gradual release from stored sperm may function to prolong PMR and enhance male reproductive success.DISRUPTION PHENOTYPE Viable and fertile (PubMed:19793753). Males are able to transfer sperm but can only induce weak PMR behaviors in females (PubMed:12897240, PubMed:19793753). Males display dramatic defects in the morphology of large neutral lipid-containing microcarriers produced by accessory gland main cells; microcarriers are enlarged and fail to dissassembl properly in females after mating (PubMed:33495334). RNAi-mediated knockdown in accessory gland main cells results in production of enlarged lipid-containing microcarriers in seminal fluid (PubMed:33495334).SIMILARITY Belongs to the Drosophila sex peptide family. |
| description | recommendedName: fullName evidence="15"Sex peptide alternativeName: Accessory gland-specific peptide 70A alternativeName: Paragonial peptide B |
| geneName | SP Acp70A PAPB CG17673 |
| identifier | P05623 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Behavior Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hydroxylation Reference proteome Secreted Signal |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6791590] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | SP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | A70A_DROME O18659 Q4V3K7 Q6VBF8 Q9VU54 |
| sequenceLength | 55 |
| species | [Species:56210] Drosophila melanogaster |
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No pathways have been reviewed or authored by UniProt:P05623 SP (84309)
