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Details on Person UniProt:P21588 Nt5e
| Class:Id | ReferenceGeneProduct:84193 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-551 added on Fri February 6 2015;propeptide:552-576 added on Fri February 6 2015 |
| _displayName | UniProt:P21588 Nt5e |
| _timestamp | 2025-02-21 19:24:47 |
| chain | signal peptide:1-28 chain:29-551 propeptide:552-576 |
| checksum | 9EB75DD51E678AA6 |
| comment | FUNCTION Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside (PubMed:1770988). AMP is the preferred substrate but can also hydrolyze CMP and GMP (PubMed:1770988). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Other substrates include IMP, UMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity).CATALYTIC ACTIVITY a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphateCATALYTIC ACTIVITY a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphateCATALYTIC ACTIVITY dTMP + H2O = thymidine + phosphateCATALYTIC ACTIVITY CMP + H2O = cytidine + phosphateCATALYTIC ACTIVITY IMP + H2O = inosine + phosphateCATALYTIC ACTIVITY AMP + H2O = adenosine + phosphateCATALYTIC ACTIVITY GMP + H2O = guanosine + phosphateCATALYTIC ACTIVITY UMP + H2O = uridine + phosphateCATALYTIC ACTIVITY dAMP + H2O = 2'-deoxyadenosine + phosphateCATALYTIC ACTIVITY dCMP + H2O = 2'-deoxycytidine + phosphateCOFACTOR Homodimer.SUBCELLULAR LOCATION Expressed in the brain.SIMILARITY Belongs to the 5'-nucleotidase family. |
| description | recommendedName: 5'-nucleotidase shortName: 5'-NT ecNumber evidence="1"3.1.3.35 ecNumber evidence="3"3.1.3.5 ecNumber evidence="1"3.1.3.89 ecNumber evidence="3"3.1.3.91 ecNumber evidence="1"3.1.3.99 alternativeName: fullName evidence="1"5'-deoxynucleotidase alternativeName: Ecto-5'-nucleotidase alternativeName: fullName evidence="1"IMP-specific 5'-nucleotidase alternativeName: fullName evidence="1"Thymidylate 5'-phosphatase cdAntigenNameCD73/cdAntigenName |
| geneName | Nt5e Nt5 Nte |
| identifier | P21588 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Metal-binding Nucleotide-binding Reference proteome Signal Zinc |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Nt5e |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | 5NTD_RAT |
| sequenceLength | 576 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:109267] 5 nucleotidase [plasma membrane] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:P21588 Nt5e (84193)
