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Details on Person UniProt:P36179 Pp2A-29B
| Class:Id | ReferenceGeneProduct:84109 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-591 added on Fri February 6 2015;initiator methionine:1 for 84109 removed on Fri Nov 03 2023;initiator methionine: for 84109 added on Fri Nov 03 2023;initiator methionine: for 84109 removed on Fri Aug 15 2025;initiator methionine:1 for 84109 added on Fri Aug 15 2025 |
| _displayName | UniProt:P36179 Pp2A-29B |
| _timestamp | 2025-08-15 21:27:56 |
| chain | initiator methionine:1 chain:2-591 |
| checksum | 13948F39796662AC |
| comment | FUNCTION The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:32966759). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, acts as a scaffolding subunit for mts/PP2A, which catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and Spt5, thereby preventing transcriptional elongation (PubMed:32966759).SUBUNIT PP2A exists in several trimeric forms, all of which consist of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit (PR65) (subunit A) (By similarity). The core complex associates with a third, variable subunit (subunit B), which confers distinct properties to the holoenzyme (By similarity). Interacts with the inorganic phosphate transporter PXo (CG10483) (PubMed:37138087). Component of the Integrator-PP2A (INTAC) complex, composed of the Integrator core complex and protein phosphatase 2A subunits mts/PP2A and Pp2A-29B (PubMed:32966759, PubMed:37995689, PubMed:39032490).INTERACTION Expression varies in tissues throughout development. Highly distributed expression in early embryos. In late embryonal development, found at high levels in nervous system and gonads. In third instar larvae, found in brain, imaginal disks and salivary glands.DEVELOPMENTAL STAGE Expressed both maternally and zygotically. Expressed at lower levels in larvae and adult.DOMAIN Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.SIMILARITY Belongs to the phosphatase 2A regulatory subunit A family.SEQUENCE CAUTION Intron retention. |
| description | recommendedName: Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit alternativeName: PR65 alternativeName: Protein phosphatase PP2A regulatory subunit A |
| geneName | Pp2A-29B CG17291 |
| identifier | P36179 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Nucleus Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Pp2A-29B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | 2AAA_DROME A4V0F7 Q2MGK6 Q5BI19 Q9VLN3 |
| sequenceLength | 591 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:205936] PP2A-29B [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:432394] PP2A-29B [nucleoplasm] [Drosophila melanogaster] |
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No pathways have been reviewed or authored by UniProt:P36179 Pp2A-29B (84109)
