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Details on Person Cross-linking experiments performed in the yeast system have...
| Class:Id | Summation:83765 |
|---|---|
| _displayName | Cross-linking experiments performed in the yeast system have... |
| _timestamp | 2017-04-10 11:15:25 |
| created | [InstanceEdit:75942] Hernandez, N, 2003-09-11 07:42:29 |
| literatureReference | [LiteratureReference:1964443] Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation [LiteratureReference:8984620] Orientation and topography of RNA polymerase III in transcription complexes [LiteratureReference:8984624] Interaction between a complex of RNA polymerase III subunits and the 70-kDa component of transcription factor IIIB [LiteratureReference:8984656] Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing [LiteratureReference:8984651] The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex [LiteratureReference:8984638] S. cerevisiae TFIIIB is the transcription initiation factor proper of RNA polymerase III, while TFIIIA and TFIIIC are assembly factors [LiteratureReference:8984693] Cloning, expression, and function of TFC5, the gene encoding the B" component of the Saccharomyces cerevisiae RNA polymerase III transcription factor TFIIIB |
| modified | [InstanceEdit:83823] Gillespie, ME, 2003-12-01 00:00:00 [InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00 [InstanceEdit:8984615] Duenas, Corina, 2017-04-10 |
| text | Cross-linking experiments performed in the yeast system have shown that within the transcription initiation complex, eight RNA polymerase III subunits can be cross-linked to DNA (Bartholomew et al., 1993). The C34 subunit, which is known to be required specifically for transcription initiation but not elongation (Wang and Roeder, 1997; Werner et al., 1993), maps the furthest upstream of the transcription start site, in close proximity to Brf1-TFIIIB (Bartholomew et al., 1993). Indeed, this subunit interacts with Brf1 (Khoo et al., 1994; Werner et al., 1993). The figure illustrates this and other protein-protein contacts involving RNA polymerase III subunits and either TFIIIC or Brf1-TFIIIB subunits. The contacts identified with S. cerevisiae proteins are indicated by stippled arrows, those identified with human protein by solid arrows. Both the S. cerevisiae RNA polymerase III subunits C53 and ABC10a interact with Tfc4 ( 1999; Flores et al., 1999), and both C17 and C34 interact with Brf1. The human subunit RPC62 interacts with TIIIC63, and RPC39 with the TFIIIC subunits TFIIIC90 and TFIIIC63 (Hsieh et al., 1999a) and the Brf1-TFIIIB subunits Brf1 and TBP (Wang and Roeder, 1997). The contacts between RNA polymerase III and TFIIIC subunits are not absolutely required for transcription in vitro with the S. cerevisiae system, in which TFIIIC can be stripped from the DNA after assembly of TFIIIB without compromising transcription (Kassavetis et al., 1990) or, indeed, where transcription can be performed in the absence of TFIIIC on TATA box-containing promoters (Kassavetis et al., 1995). Nevertheless, they may contribute to the recruitment of RNA polymerase III in vivo. |
| (summation) | [Reaction:76056] Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex [Homo sapiens] |
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