Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person TFIIIA contains nine C2H2 zinc fingers (Arakawa et al., 1995...

Class:IdSummation:83739
_displayNameTFIIIA contains nine C2H2 zinc fingers (Arakawa et al., 1995...
_timestamp2003-12-01 21:12:57
created[InstanceEdit:75942] Hernandez, N, 2003-09-11 07:42:29
literatureReference[LiteratureReference:83740] Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA
[LiteratureReference:83741] A specific transcription factor that can bind either the 5S RNA gene or 5S RNA
[LiteratureReference:83743] Definition of the binding sites of individual zinc fingers in the transcription factor IIIA-5S RNA gene complex
[LiteratureReference:83745] Energetically unfavorable interactions among the zinc fingers of transcription factor IIIA when bound to the 5 S rRNA gene
modified[InstanceEdit:83823] Gillespie, ME, 2003-12-01 00:00:00
textTFIIIA contains nine C2H2 zinc fingers (Arakawa et al., 1995). It binds to both the ICR region of the 5S RNA genes and to 5S RNA to form the 7S storage ribonucleoprotein particle (Pelham and Brown, 1980). Upon TFIIIA binding to the 5S gene, the TFIIIA zinc fingers are aligned over the length of the ICR with the C-terminal zinc fingers in proximity to the 5 end, and the N-terminal zinc fingers in proximity to the 3 end, of the ICR. Zinc fingers 1-3 contact the C block within the ICR and have been reported to contribute most of the binding energy of the full-length protein (Clemens et al., 1992). However, TFIIIA fragments containing zinc fingers 4-9 bind to the A block and intermediate element within the ICR with affinities close to those of the full-length protein. This and other observations suggest that simultaneous binding by all nine TFIIIA zinc fingers requires energetically unfavorable distortions within the DNA, the protein, or both (Kehres et al., 1997).
(summation)[Reaction:76052] Binding of TFIIIA To type 1 Promoter [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by TFIIIA contains nine C2H2 zinc fingers (Arakawa et al., 1995... (83739)
Follow Reactome