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Details on Person TNF:TNFR1 binds TRADD, TRAF2 and RIPK1

Class:IdReaction:83656
_displayNameTNF:TNFR1 binds TRADD, TRAF2 and RIPK1
_doReleaseTRUE
_timestamp2016-11-10 00:56:15
authored[InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:110071] Tschopp, Jürg, 2004-01-28
edited[InstanceEdit:3371404] Shamovsky, V, 2013-05-13
input[EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:168651] RIPK1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens]
[DefinedSet:3371401] TNF-α trimer:TNFR1 trimer [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:66376] TRADD [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:66370] TRAF2 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:140948] The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
modified[InstanceEdit:83892] Matthews, L, 2003-12-10 03:30:00
[InstanceEdit:109912] Joshi-Tope, G, 2004-01-21 22:18:55
[InstanceEdit:110070] Joshi-Tope, G, 2004-01-28 14:40:07
[InstanceEdit:140952] Gillespie, ME, 2004-08-24 21:33:15
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:386963] Williams, MG, 2008-11-27 15:33:38
[InstanceEdit:2648974] D'Eustachio, P, 2012-11-21
[InstanceEdit:3006723] Jassal, B, 2013-02-01
[InstanceEdit:3371406] Shamovsky, V, 2013-05-13
[InstanceEdit:3465520] Shamovsky, V, 2013-05-17
[InstanceEdit:3597633] Shamovsky, V, 2013-05-22
[InstanceEdit:3632866] Shamovsky, V, 2013-05-28
[InstanceEdit:5334691] Gillespie, Marc E, 2014-02-24
[InstanceEdit:5692560] Shamovsky, Veronica, 2015-05-12
[InstanceEdit:6792553] Shamovsky, Veronica, 2015-08-25
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTNF:TNFR1 binds TRADD, TRAF2 and RIPK1
output[Complex:140946] TNF-α:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2004-10-27
reviewed[InstanceEdit:386956] Silverman, N, Lemaitre, B, 2008-06-20 10:21:55
[InstanceEdit:3597630] Pop, Cristina, Salvesen, Guy S., 2013-05-22
[InstanceEdit:6792551] Wajant, Harald, 2015-08-25
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:3465563] Shamovsky, V, 2013-05-17
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361068] R-HSA-83656.4
summation[Summation:74302] Once the TNF-α:TNFR1:TRADD:RIPK1 complex has been formed the...
(hasEvent)[Pathway:75893] TNF signaling [Homo sapiens]
[Pathway:209395] Imd pathway - Inferred Events
(inferredFrom)[Reaction:209221] Assembly of the PGN:PGRP-LC oligomer receptor 'signalling complex' [Drosophila melanogaster]
[Reaction:214405] Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex' [Drosophila melanogaster]
(normalReaction)[Reaction:5334740] HPV Suppressed TNF:TNF-R1 binds TRADD, TRAF2 and RIP [Homo sapiens]
(precedingEvent)[Reaction:83582] TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1 [Homo sapiens]
[Reaction:5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) [Homo sapiens]
[Reaction:5627608] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits S1P [Homo sapiens]
[Reaction:8850585] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds MAP4K2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784273] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v54:[modifyText]
[_UpdateTracker:9784647] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v53:[modifyText]
[_UpdateTracker:9784866] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v52:[modifyText]
[_UpdateTracker:9786460] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v49:[removeRegulator]
[_UpdateTracker:9787345] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v45:[add_removeInput]
[_UpdateTracker:9787949] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v44:[addRegulator, add_removeInput]
[_UpdateTracker:9847052] Update Tracker - [Reaction:83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - v82:[modifyText]
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