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Details on Person ATM mediated phosphorylation of MDC1/NFBD1 may be involved i...

Class:Id	Summation:83587
_displayName	ATM mediated phosphorylation of MDC1/NFBD1 may be involved i...
_timestamp	2015-05-16 06:56:44
created	[InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00
literatureReference	[LiteratureReference:83588] NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. [LiteratureReference:83562] MDC1 is a mediator of the mammalian DNA damage checkpoint. [LiteratureReference:83563] MDC1 is required for the intra-S-phase DNA damage checkpoint.
modified	[InstanceEdit:83683] Matthews, L, 2003-11-27 03:00:00 [InstanceEdit:5682535] Orlic-Milacic, Marija, 2015-03-07 [InstanceEdit:5682566] Orlic-Milacic, Marija, 2015-03-09 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
text	ATM mediated phosphorylation of MDC1/NFBD1 may be involved in the rapid relocalization of MDC1/NFBD1 to nuclear foci that contain the MRE11 complex, phosphorylated histone H2AX and 53BP1 (Goldberg et al., 2003). NFBD1 may also function in recruiting DNA checkpoint signaling and repair proteins to the sites of DNA damage (Xu and Stern., 2003 and Stewart et al.,2003).
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