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Details on Person Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2

Class:Id	Reaction:77319
_displayName	Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2
_doRelease	TRUE
_timestamp	2025-12-30 14:34:57
catalystActivity	[CatalystActivity:77317] acyl-CoA dehydrogenase activity of ACADS tetramer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:77247] Gillespie, ME, 2003-09-19 00:00:00
crossReference	[DatabaseIdentifier:9977726] RHEA:30732
input	[SimpleEntity:113596] FAD [mitochondrial matrix] [SimpleEntity:77318] BT-CoA [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
internalReviewed	[InstanceEdit:9978289] D'Eustachio, Peter, 2025-12-29
literatureReference	[LiteratureReference:77398] On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein. [LiteratureReference:70739] Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver
modified	[InstanceEdit:77397] Gillespie, ME, 2003-10-25 00:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:8878102] Jassal, Bijay, 2016-06-30 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9977727] D'Eustachio, Peter, 2025-12-22 [InstanceEdit:9978288] D'Eustachio, Peter, 2025-12-29 [InstanceEdit:9978313] D'Eustachio, Peter, 2025-12-30
name	Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2 butanoyl-CoA + FAD + H(+) => (2E)-butenoyl-CoA + FADH2
output	[SimpleEntity:31649] FADH2 [mitochondrial matrix] [SimpleEntity:77313] Crotonoyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:77321] 3-Oxohexanoyl-CoA+CoA-SH => Butanoyl-CoA + acetyl-CoA [Homo sapiens] [Reaction:77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H [Homo sapiens] [Reaction:8875013] ACSM3,ACSM6 ligate CoA to BUT [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9978314] D'Eustachio, Peter, 2025-12-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361283] R-HSA-77319.5
structureModified	[InstanceEdit:9977727] D'Eustachio, Peter, 2025-12-22
summation	[Summation:178523] ACADS in the mitochondrial matrix dehydrogenates butanoyl-Co...
(hasEvent)	[Pathway:77352] Beta oxidation of butanoyl-CoA to acetyl-CoA [Homo sapiens]
(precedingEvent)	[Reaction:77314] Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA [Homo sapiens] [Reaction:169260] Reducing equivalents from beta-oxidation of fatty acids transfer to ETF [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984738] Update Tracker - [Reaction:77319] Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2 - v96:[modifyText, removeInput]
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No pathways have been reviewed or authored by Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2 (77319)