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Details on Person Methylation of GMP-cap by RNA Methyltransferase

Class:Id	Reaction:77090
_displayName	Methylation of GMP-cap by RNA Methyltransferase
_doRelease	TRUE
_timestamp	2026-05-14 23:30:59
authored	[InstanceEdit:77054] Buratowski, S, 2003-10-15 15:18:41
catalystActivity	[CatalystActivity:72082] mRNA 5'-cap (guanine-N7-)-methyltransferase activity of Capping complex (with freed 5'- GMP) [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:77054] Buratowski, S, 2003-10-15 15:18:41
figure	[Figure:77487] /figures/Cap1c.jpg
input	[Complex:77067] Capping complex (with freed 5'- GMP) [nucleoplasm] [Homo sapiens] [SimpleEntity:77087] AdoMet [nucleoplasm]
internalReviewed	[InstanceEdit:9989102] D'Eustachio, Peter, 2026-05-14
literatureReference	[LiteratureReference:77483] Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. [LiteratureReference:9989091] Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations [LiteratureReference:9989092] RAM/Fam103a1 is required for mRNA cap methylation
modified	[InstanceEdit:77027] Gopinathrao, G, 2003-10-15 15:18:37 [InstanceEdit:77367] Joshi-Tope, G, 2003-10-17 16:16:00 [InstanceEdit:77479] Gopinathrao, G, 2003-10-29 09:19:11 [InstanceEdit:77503] Gopinathrao, G, 2003-10-29 14:55:30 [InstanceEdit:111340] Gopinathrao, G, 2004-02-12 15:30:00 [InstanceEdit:113400] Gopinathrao, G, 2004-05-06 22:00:00 [InstanceEdit:159378] Gopinathrao, G, 2005-03-07 18:19:33 [InstanceEdit:159379] Gopinathrao, G, 2005-03-07 18:29:36 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:167005] Schmidt, EE, 2005-10-10 15:17:32 [InstanceEdit:350781] Gopinathrao, G, 2008-05-20 17:45:26 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:3009364] Jassal, B, 2013-02-05 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9989093] D'Eustachio, Peter, 2026-05-14 [InstanceEdit:9989103] D'Eustachio, Peter, 2026-05-14 [InstanceEdit:9989105] D'Eustachio, Peter, 2026-05-14
name	Methylation of GMP-cap by RNA Methyltransferase
output	[SimpleEntity:77502] AdoHcy [nucleoplasm] [Complex:113403] mRNA capping factors [nucleoplasm] [Homo sapiens] [Complex:113405] RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] [Homo sapiens] [Complex:109634] TFIIH [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3009372] p-SUPT5H [nucleoplasm] [Homo sapiens] [Complex:9989096] RNMT:RAMAC [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:77085] Dissociation of transcript with 5'-GMP from GT [Homo sapiens] [Reaction:77083] Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9989106] Hill, David P, 2026-05-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361624] R-HSA-77090.3
structureModified	[InstanceEdit:9989093] D'Eustachio, Peter, 2026-05-14
summation	[Summation:77091] In the final step of the capping reaction, the methyltransfe...
(hasEvent)	[Pathway:72086] mRNA Capping [Homo sapiens]
(inferredFrom)	[Reaction:167395] Methylation of GMP-cap by RNA Methyltransferase [Homo sapiens] [Reaction:1113135] Methylation of GMP-cap by RNA Methyltransferase [Oryza sativa]
(orthologousEvent)	[Reaction:1113135] Methylation of GMP-cap by RNA Methyltransferase [Oryza sativa]
(precedingEvent)	[Reaction:77095] Recognition and binding of the mRNA cap by the cap-binding complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9787876] Update Tracker - [Reaction:77090] Methylation of GMP-cap by RNA Methyltransferase - v44:[add_removeOutput] [_UpdateTracker:9791904] Update Tracker - [Reaction:77090] Methylation of GMP-cap by RNA Methyltransferase - v25:[add_removeOutput]
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