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Details on Person After the capping complex is formed, the RNA triphosphatase ...
| Class:Id | Summation:77079 |
|---|---|
| _displayName | After the capping complex is formed, the RNA triphosphatase ... |
| _timestamp | 2004-02-12 20:48:22 |
| created | [InstanceEdit:77054] Buratowski, S, 2003-10-15 15:18:41 |
| modified | [InstanceEdit:77106] Gopinathrao, G, 2003-10-16 13:51:52 [InstanceEdit:77367] Joshi-Tope, G, 2003-10-17 16:16:00 [InstanceEdit:77479] Gopinathrao, G, 2003-10-29 09:19:11 [InstanceEdit:77503] Gopinathrao, G, 2003-10-29 14:55:30 [InstanceEdit:77578] Gopinathrao, G, 2003-10-31 12:19:58 [InstanceEdit:111340] Gopinathrao, G, 2004-02-12 15:30:00 |
| text | After the capping complex is formed, the RNA triphosphatase activity of the capping enzyme hydrolyzes the 5'-end phosphate group of the nascent mRNA transcript to a diphosphate. The RNA triphosphatase (RTP) domain of mammalian capping enzyme is a member of a superfamily of phosphatases that include the protein tyrosine phosphatases, some lipid phosphatases, and several nucleic acid phosphatases. This family uses a conserved nucleophilic cysteine residue to attack the target phosphate. A transient phospho-cysteinyl enzyme intermediate is then hydrolyzed to regenerate the enzyme active site. It should be noted that while higher eukaryotic capping enzymes use PTP-like triphosphatase domains, the yeast triphosphatases are a completely different class of enzymes. The yeast RTPs are metal-dependent phosphatases. RNA 5'-triphosphatase (RTP) catalyzed first reaction can be represented as:pppN(pN)n + GTP -> ppN(pN)n + Pi; (n=20-25) |
| (summation) | [Reaction:77078] Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme [Homo sapiens] [Reaction:167400] Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme [Homo sapiens] |
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