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Details on Person UniProt:O43148 RNMT
| Class:Id | ReferenceGeneProduct:77059 |
|---|---|
| _chainChangeLog | chain:1-476 added on Fri February 6 2015 |
| _displayName | UniProt:O43148 RNMT |
| _timestamp | 2025-02-21 19:39:56 |
| chain | chain:1-476 |
| checksum | EC919BC41BD5E2B3 |
| comment | FUNCTION Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).CATALYTIC ACTIVITY a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteineACTIVITY REGULATION Methyltransferase activity is activated by RAMAC (PubMed:27422871).SUBUNIT Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity (PubMed:11114884). Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates (PubMed:11114884). Interacts with elongating form of polymerase II and RNGTT (PubMed:9705270). Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity (PubMed:22099306, Ref.14).INTERACTION Widely expressed.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. |
| created | [InstanceEdit:77027] Gopinathrao, G, 2003-10-15 15:18:37 |
| description | recommendedName: mRNA cap guanine-N(7) methyltransferase ecNumber evidence="5 9 10 11"2.1.1.56 alternativeName: RG7MT1 alternativeName: mRNA (guanine-N(7))-methyltransferase alternativeName: mRNA cap methyltransferase shortName: hCMT1 shortName: hMet shortName: hcm1p |
| geneName | RNMT KIAA0398 |
| identifier | O43148 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Methyltransferase mRNA capping mRNA processing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding S-adenosyl-L-methionine Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | RNMT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004233] ENSEMBL:ENSG00000101654 RNMT [Homo sapiens] |
| secondaryIdentifier | MCES_HUMAN B0YJ90 D3DUJ5 O94996 Q9UIJ9 |
| sequenceLength | 476 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:236840] UniProt:O43148-2 RNMT [Homo sapiens] [ReferenceIsoform:401483] UniProt:O43148-1 RNMT [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:77060] RNMT [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43148 RNMT (77059)
