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Details on Person AMP + H2O => IMP + NH4+ (AMPD)

Class:Id	Reaction:76590
_displayName	AMP + H2O => IMP + NH4+ (AMPD)
_doRelease	TRUE
_timestamp	2025-12-16 18:01:21
catalystActivity	[CatalystActivity:76587] AMP deaminase activity of AMPD tetramers [cytosol]
catalystActivityReference	[CatalystActivityReference:9644036] AMP deaminase activity of AMPD tetramers [cytosol] Platelet AMP deaminase. Purification and kinetic studies
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:76579] D'Eustachio, P, 2003-10-11 14:30:00
crossReference	[DatabaseIdentifier:9976240] RHEA:14778
input	[SimpleEntity:76577] AMP [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:70106] H+ [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:500239] Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA [LiteratureReference:500240] Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms
modified	[InstanceEdit:164640] D'Eustachio, P, 2005-06-08 20:26:05 [InstanceEdit:500236] D'Eustachio, P, 2010-02-01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:508577] D'Eustachio, P, 2010-02-14 [InstanceEdit:525791] D'Eustachio, P, 2010-02-22 [InstanceEdit:597586] D'Eustachio, P, 2010-04-13 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9731667] D'Eustachio, Peter, 2021-05-21 [InstanceEdit:9737490] D'Eustachio, Peter, 2021-07-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	AMP + H2O => IMP + NH4+ (AMPD) AMP + H2O + H(+) => IMP + NH4(+)
output	[SimpleEntity:31633] NH4+ [cytosol] [SimpleEntity:29602] IMP [cytosol]
precedingEvent	[Reaction:74213] APRT catalyzes the conversion of adenine to AMP [Homo sapiens] [Reaction:73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate [Homo sapiens] [Reaction:111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360188] R-HSA-76590.7
structureModified	[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation	[Summation:178441] Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of A...
(hasEvent)	[Pathway:74217] Purine salvage [Homo sapiens]
(precedingEvent)	[Reaction:74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) [Homo sapiens]
(replacementInstances)	[_Deleted:500241] Deletion of instances: 76603, 76597
(updatedInstance)	[_UpdateTracker:9790790] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v33:[add_removeOutput] [_UpdateTracker:9791205] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v32:[add_removeLiteratureReference, add_removeOutput, modifyText] [_UpdateTracker:9984659] Update Tracker - [Reaction:76590] AMP + H2O => IMP + NH4+ (AMPD) - v96:[removeInput]
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No pathways have been reviewed or authored by AMP + H2O => IMP + NH4+ (AMPD) (76590)