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Details on Person PTGIS, CYP8A1 isomerise PGH2 to PGI2

Class:IdReaction:76496
_displayNamePTGIS, CYP8A1 isomerise PGH2 to PGI2
_doReleaseTRUE
_timestamp2024-07-12 21:31:47
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:76495] prostaglandin-I synthase activity of PTGIS,CYP8B1 [endoplasmic reticulum membrane]
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:17957] endoplasmic reticulum lumen
created[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
crossReference[DatabaseIdentifier:9915649] RHEA:23581
edited[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
input[SimpleEntity:30138] PGH2 [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:215548] Purification and characterization of recombinant human prostacyclin synthase
[LiteratureReference:5362158] 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
modified[InstanceEdit:76554] Jassal, B, 2003-10-10 05:22:25
[InstanceEdit:139962] Jassal, B, 2004-08-11 05:47:32
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:211788] Jassal, B, 2008-02-08 15:20:21
[InstanceEdit:211846] Jassal, B, 2008-02-08 15:31:08
[InstanceEdit:215522] Jassal, B, 2008-03-04 14:20:48
[InstanceEdit:265299] Jassal, B, 2008-04-17 12:29:21
[InstanceEdit:266094] Jassal, B, 2008-04-22 08:44:12
[InstanceEdit:350190] Jassal, B, 2008-05-14 09:43:45
[InstanceEdit:350227] Jassal, B, 2008-05-15 08:19:12
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:350849] Jassal, B, 2008-05-21 10:36:56
[InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10
[InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30
[InstanceEdit:352333] Jassal, B, 2008-06-02 13:27:43
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:2162166] Williams, MG, 2012-03-14
[InstanceEdit:2201180] Williams, MG, 2012-04-17
[InstanceEdit:2309789] D'Eustachio, P, 2012-06-05
[InstanceEdit:2569041] D'Eustachio, P, 2012-11-10
[InstanceEdit:5362166] Jassal, B, 2014-04-15
[InstanceEdit:8940088] Jassal, Bijay, 2016-09-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915663] D'Eustachio, Peter, 2024-07-12
namePTGIS, CYP8A1 isomerise PGH2 to PGI2
prostaglandin H2 => prostaglandin I2
Prostacyclin synthase (CYP8A1) mediates the isomerization of prostaglandin H2 to prostaglandin I2
output[SimpleEntity:31593] PGI2 [endoplasmic reticulum lumen]
precedingEvent
releaseDate2008-06-30
reviewed[InstanceEdit:2569042] Rush, MG, 2012-11-10
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:8940089] Jassal, Bijay, 2016-09-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358538] R-HSA-76496.4
summation[Summation:76555] Prostacyclin synthase (PTGIS) aka CYP8A1 mediates the isomer...
(hasEvent)[Pathway:211979] Eicosanoids [Homo sapiens]
[Pathway:2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) [Homo sapiens]
(precedingEvent)[Reaction:2161619] PGI2 is hydrolysed to 6k-PGF1a [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786559] Update Tracker - [Reaction:76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - v49:[addLiteratureReference, modifyText]
[_UpdateTracker:9788577] Update Tracker - [Reaction:76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - v41:[modifyText, removeInput]
[_UpdateTracker:9791833] Update Tracker - [Reaction:76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - v25:[add_removeLiteratureReference]
[_UpdateTracker:9791998] Update Tracker - [Reaction:76496] PTGIS, CYP8A1 isomerise PGH2 to PGI2 - v24:[add_removeLiteratureReference]
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