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Details on Person POR reduces CYP450:Fe3+ to CYP450:Fe2+

Class:IdReaction:76494
_displayNamePOR reduces CYP450:Fe3+ to CYP450:Fe2+
_doReleaseTRUE
_timestamp2025-05-30 18:51:09
authored[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
catalystActivity[CatalystActivity:76491] NADPH-hemoprotein reductase activity of POR [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9947132] NADPH-hemoprotein reductase activity of POR [endoplasmic reticulum membrane] NADPH P450 oxidoreductase: structure, function, and pathology of diseases
compartment[Compartment:12045] endoplasmic reticulum membrane
[Compartment:70101] cytosol
created[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
crossReference[DatabaseIdentifier:9947123] RHEA:24041
edited[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
goBiologicalProcess[GO_BiologicalProcess:9750490] P450-containing electron transport chain
input[SimpleEntity:29364] NADPH [cytosol]
[Complex:8957351] CYP450:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:8957351] CYP450:Fe3+ [endoplasmic reticulum membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9947140] D'Eustachio, Peter, 2025-05-01
literatureReference[LiteratureReference:8847922] Modification of the nucleotide cofactor-binding site of cytochrome P-450 reductase to enhance turnover with NADH in Vivo
[LiteratureReference:6806906] Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes
[LiteratureReference:9947125] Mechanisms of Cytochrome P450-Catalyzed Oxidations
[LiteratureReference:9947126] Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components
[LiteratureReference:9947128] NADPH P450 oxidoreductase: structure, function, and pathology of diseases
[LiteratureReference:6806902] Quantification of cytochrome P450 reductase gene expression in human tissues
modified[InstanceEdit:6806924] Jassal, Bijay, 2015-10-28
[InstanceEdit:8847923] Jassal, Bijay, 2015-12-03
[InstanceEdit:8850391] Jassal, Bijay, 2015-12-21
[InstanceEdit:8851786] Jassal, Bijay, 2016-01-11
[InstanceEdit:8862020] Jassal, Bijay, 2016-02-24
[InstanceEdit:8957353] Jassal, Bijay, 2017-01-25
[InstanceEdit:8957375] Jassal, Bijay, 2017-01-25
[InstanceEdit:9707094] D'Eustachio, Peter, 2020-11-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9947129] D'Eustachio, Peter, 2025-05-01
[InstanceEdit:9947147] D'Eustachio, Peter, 2025-05-01
[InstanceEdit:9947210] D'Eustachio, Peter, 2025-05-02
[InstanceEdit:9947452] D'Eustachio, Peter, 2025-05-05
[InstanceEdit:9953268] D'Eustachio, Peter, 2025-05-30
namePOR reduces CYP450:Fe3+ to CYP450:Fe2+
2 oxidized (cytochrome P450) + NADPH => 2 reduced (cytochrome P450) + NADP(+) + H(+)
output[SimpleEntity:29366] NADP+ [cytosol]
[Complex:8957354] CYP450:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens]
[Complex:8957354] CYP450:Fe2+ [endoplasmic reticulum membrane] [Homo sapiens]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2016-03-23
releaseStatusNEW
reviewed[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
[InstanceEdit:9953269] Hill, David P, 2025-05-30
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8860961] R-HSA-76494.5
structureModified[InstanceEdit:9947129] D'Eustachio, Peter, 2025-05-01
summation[Summation:6806918] NADPH-cytochrome P450 reductase (POR) was first identified a...
(hasEvent)[Pathway:211897] Cytochrome P450 - arranged by substrate type [Homo sapiens]
[Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)[Reaction:6807053] SC5D desaturates LTHSOL to 7-dehydroCHOL [Homo sapiens]
[Reaction:9947148] CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol [Homo sapiens]
[Reaction:9947203] MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol [Homo sapiens]
[Reaction:9947207] MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781786] Update Tracker - [Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ - v60:[add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9953670] Update Tracker - [Reaction:76494] POR reduces CYP450:Fe3+ to CYP450:Fe2+ - v93:[add_removeLiteratureReference, modifyText, removeOutput]
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