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Details on Person Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide

Class:Id	Reaction:76475
_displayName	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
_doRelease	TRUE
_timestamp	2008-06-20 09:40:06
authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76353] monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
goBiologicalProcess	[GO_BiologicalProcess:8797] halogenated hydrocarbon metabolic process
input	[SimpleEntity:40795] HALO [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:211839] Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro [LiteratureReference:211836] Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis
modified	[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20 [InstanceEdit:139962] Jassal, B, 2004-08-11 05:47:32 [InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194325] Jassal, B, 2007-03-13 15:29:38 [InstanceEdit:211781] Jassal, B, 2008-02-08 15:19:57 [InstanceEdit:211782] Jassal, B, 2008-02-08 15:20:00 [InstanceEdit:211783] Jassal, B, 2008-02-08 15:20:04 [InstanceEdit:211834] Jassal, B, 2008-02-08 15:27:33 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:351778] Jassal, Bijay, 2008-05-28 [InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
output	[SimpleEntity:76473] TFAC [endoplasmic reticulum lumen] [SimpleEntity:76474] HBr [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358893] R-HSA-76475.2
summation	[Summation:211840] The volatile anesthetic halothane can undergo CYP2E1-catalyz...
(hasEvent)	[Pathway:211999] CYP2E1 reactions [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791992] Update Tracker - [Reaction:76475] Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide - v24:[add_removeLiteratureReference, add_removeSummation]
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