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Details on Person O-atom dealkylation of dextromethorphan

Class:Id	Reaction:76456
_displayName	O-atom dealkylation of dextromethorphan
_doRelease	TRUE
_timestamp	2020-06-03 13:14:45
catalystActivity	[CatalystActivity:76454] monooxygenase activity of Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen [Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
input	[ChemicalDrug:39703] DEXM [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn
modified	[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20 [InstanceEdit:143500] Schmidt, EE, 2004-11-11 15:37:02 [InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194325] Jassal, B, 2007-03-13 15:29:38 [InstanceEdit:2656455] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9690610] Jassal, Bijay, 2020-06-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	O-atom dealkylation of dextromethorphan
output	[ChemicalDrug:76455] DEXT [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen] [SimpleEntity:143501] CH2O [endoplasmic reticulum lumen]
releaseDate	2005-02-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105355] R-HSA-76456.4
summation	[Summation:178667] At the beginning of this reaction, 1 molecule of 'H+', 1 mol...
(hasEvent)	[Pathway:211981] Xenobiotics [Homo sapiens]
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No pathways have been reviewed or authored by O-atom dealkylation of dextromethorphan (76456)