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Details on Person Benzene is hydroxylated to phenol

Class:Id	Reaction:76416
_displayName	Benzene is hydroxylated to phenol
_doRelease	TRUE
_timestamp	2008-06-20 09:40:23
authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76353] monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
goBiologicalProcess	[GO_BiologicalProcess:11828] benzene metabolic process
input	[SimpleEntity:31711] C6H6 [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:211822] Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite
modified	[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20 [InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:211784] Jassal, B, 2008-02-08 15:20:07 [InstanceEdit:211821] Jassal, B, 2008-02-08 15:25:05 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:351777] Jassal, B, 2008-05-28 08:44:17 [InstanceEdit:352324] Jassal, B, 2008-06-02 12:56:30 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Benzene is hydroxylated to phenol Benzene + O₂ + NADPH + H⁺ -> Phenol + H₂O + NADP⁺
output	[SimpleEntity:29630] PhOH [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359078] R-HSA-76416.2
summation	[Summation:178502] Benzene is an occupational and environmental toxicant and is...
(hasEvent)	[Pathway:211999] CYP2E1 reactions [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792035] Update Tracker - [Reaction:76416] Benzene is hydroxylated to phenol - v24:[add_removeLiteratureReference, modifyText]
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