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Details on Person Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)

Class:IdReaction:76397
_displayNameAcetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)
_doReleaseTRUE
_timestamp2008-06-20 09:41:30
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:76353] monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
compartment[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
goBiologicalProcess[GO_BiologicalProcess:8764] xenobiotic metabolic process
input[SimpleEntity:39427] Acetaminophen (TN TYLENOL) [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
[SimpleEntity:113555] H2 [endoplasmic reticulum lumen]
[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
literatureReference[LiteratureReference:211815] Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation
modified[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20
[InstanceEdit:156593] Jassal, B, 2004-11-29 13:01:16
[InstanceEdit:158905] Jassal, B, 2005-02-14 16:13:19
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:211782] Jassal, B, 2008-02-08 15:20:00
[InstanceEdit:211816] Jassal, B, 2008-02-08 15:24:27
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351776] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9758001] Weiser, JD, 2021-11-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAcetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)
output[SimpleEntity:76396] NABQI [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
releaseDate2008-06-30
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359803] R-HSA-76397.3
summation[Summation:178367] N-acetyl-p-benzoquinone imine (NAPQI) is the reactive interm...
(hasEvent)[Pathway:211999] CYP2E1 reactions [Homo sapiens]
(precedingEvent)[Reaction:176059] GST trimers transfer GS from GSH to luminal substrates [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791939] Update Tracker - [Reaction:76397] Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI) - v24:[add_removeLiteratureReference, modifyText]
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