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Details on Person CYP1A2 S-demethylates 6MMP

Class:IdReaction:76386
_displayNameCYP1A2 S-demethylates 6MMP
_doReleaseTRUE
_timestamp2016-11-10 00:55:48
catalystActivity[CatalystActivity:76372] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
compartment[Compartment:17960] smooth endoplasmic reticulum
created[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
input[SimpleEntity:76384] 6MMP [endoplasmic reticulum lumen]
[SimpleEntity:113601] NADPH [endoplasmic reticulum lumen]
[SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
[SimpleEntity:113534] O2 [endoplasmic reticulum lumen]
literatureReference[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn
modified[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20
[InstanceEdit:140961] Jassal, B, 2004-08-25 10:59:57
[InstanceEdit:143492] Jassal, B, 2004-11-11 14:00:46
[InstanceEdit:143500] Schmidt, EE, 2004-11-11 15:37:02
[InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:194325] Jassal, B, 2007-03-13 15:29:38
[InstanceEdit:5603083] Jassal, Bijay, 2014-06-27
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCYP1A2 S-demethylates 6MMP
S-atom dealkylation of 6-methylmercaptopurine
output[SimpleEntity:33153] 6MP [endoplasmic reticulum lumen]
[SimpleEntity:113519] H2O [endoplasmic reticulum lumen]
[SimpleEntity:143501] CH2O [endoplasmic reticulum lumen]
[SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
releaseDate2005-02-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358585] R-HSA-76386.3
summation[Summation:178352] At the beginning of this reaction, 1 molecule of 'H+', 1 mol...
(hasEvent)[Pathway:156581] Methylation [Homo sapiens]
(precedingEvent)[Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP [Homo sapiens]
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No pathways have been reviewed or authored by CYP1A2 S-demethylates 6MMP (76386)