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Details on Person N-hydroxylation of 4-aminobiphenyl

Class:Id	Reaction:76373
_displayName	N-hydroxylation of 4-aminobiphenyl
_doRelease	TRUE
_timestamp	2008-06-20 09:43:28
authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:76372] monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:76326] Jassal, B, 2003-08-05 00:00:00
input	[SimpleEntity:47687] ABPH [endoplasmic reticulum lumen] [SimpleEntity:113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:156540] H+ [endoplasmic reticulum lumen]
literatureReference	[LiteratureReference:211809] Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes [LiteratureReference:211812] Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
modified	[InstanceEdit:113653] Schmidt, EE, 2004-06-14 05:50:20 [InstanceEdit:156539] Jassal, B, 2004-11-19 09:05:24 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194325] Jassal, B, 2007-03-13 15:29:38 [InstanceEdit:211789] Jassal, Bijay, 2008-02-08 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:351778] Jassal, Bijay, 2008-05-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	N-hydroxylation of 4-aminobiphenyl
output	[SimpleEntity:34889] NHABP [endoplasmic reticulum lumen] [SimpleEntity:113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361078] R-HSA-76373.2
summation	[Summation:178344] Heterocyclic and aromatic amines require metabolic activatio...
(hasEvent)	[Pathway:211957] Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 [Homo sapiens]
(precedingEvent)	[Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9792045] Update Tracker - [Reaction:76373] N-hydroxylation of 4-aminobiphenyl - v24:[add_removeLiteratureReference, modifyText]
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No pathways have been reviewed or authored by N-hydroxylation of 4-aminobiphenyl (76373)