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Details on Person Butyrl-ACP formed at the end of the first cycle of FAS activ...
| Class:Id | Summation:76226 |
|---|---|
| _displayName | Butyrl-ACP formed at the end of the first cycle of FAS activ... |
| _timestamp | 2004-09-20 13:52:48 |
| created | [InstanceEdit:76212] Gopinathrao, G, 2003-10-03 00:00:00 |
| modified | [InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00 [InstanceEdit:76562] Gopinathrao, G, 2003-10-10 10:53:18 [InstanceEdit:77113] Gopinathrao, G, 2003-10-16 18:43:13 [InstanceEdit:141448] Matthews, L, 2004-09-20 15:43:00 |
| text | Butyrl-ACP formed at the end of the first cycle of FAS activity is moved on to synthase site for further elongation. C4 butryl - ACP is converted to C16 palmtoyl-ACP after 7 cycles forming beta-ketoacyl intermediates like beta-ketobutyrl (C4; first cycle) beta-ketohexanoyl (C6;second cycle) beta-ketodecanoyl (C10; fourth cycle) beta-ketododecanoyl (C12; fifth cycle) and beta-ketotetradecanoyl (C14; sixth cycle). The pathway can be visualized as a cyclic process in which an acetyl primer undergoes a series of decarboxylative condensations with seven malonyl moieties; each condensation reaction generates a 3-ketoacyl moiety that undergoes the same three-step beta-carbon reduction to give a fully saturated acyl moiety two C atoms longer than in the previous cycle. Thus, after completion of seven cycles consisting of loading elongation (condensation) and reduction phases , the final product is the saturated C16 fatty acid, palmitic acid (Smith,1994). Palmitoyl-ACP is now subjected to the thiolase activity of FAS. |
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No pathways have been reviewed or authored by Butyrl-ACP formed at the end of the first cycle of FAS activ... (76226)
