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Details on Person UniProt:O14495 PLPP3
| Class:Id | ReferenceGeneProduct:76131 |
|---|---|
| _chainChangeLog | chain:1-311 added on Sat February 7 2015 |
| _displayName | UniProt:O14495 PLPP3 |
| _timestamp | 2025-02-21 19:21:19 |
| chain | chain:1-311 |
| checksum | CB3F60189044DA31 |
| comment | FUNCTION Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:27694435, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:23591818, PubMed:27694435, PubMed:9607309). Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines (PubMed:27694435). By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function (By similarity). Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers (PubMed:23591818).FUNCTION Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth (PubMed:20123964, PubMed:21569306). Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis (PubMed:12660161, PubMed:16099422).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphateCATALYTIC ACTIVITY 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphateCATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphateCATALYTIC ACTIVITY a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphateCATALYTIC ACTIVITY (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphateCATALYTIC ACTIVITY sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphateCATALYTIC ACTIVITY an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphateCATALYTIC ACTIVITY N-(octanoyl)-sphing-4-enine-1-phosphate + H2O = N-octanoylsphing-4-enine + phosphateCATALYTIC ACTIVITY N-(9Z-octadecenoyl)-ethanolamine phosphate + H2O = N-(9Z-octadecenoyl) ethanolamine + phosphateACTIVITY REGULATION Magnesium-independent phospholipid phosphatase (PubMed:9705349). Insensitive to N-ethylmaleimide (PubMed:9705349). Inhibited by sphingosine, zinc ions and modestly by propanolol (PubMed:9705349).BIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; phospholipid metabolism.SUBUNIT Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (PubMed:14725715). Can also form heterooligomers with other PLPP2 and PLPP3 (PubMed:18215144). Interacts with CTNND1; negatively regulates the PLPP3-mediated stabilization of beta-catenin/CTNNB1 (PubMed:20123964).INTERACTION Cycles between the endoplasmic reticulum and the Golgi.TISSUE SPECIFICITY Ubiquitously expressed (PubMed:12660161, PubMed:9305923). Highly expressed in heart and placenta (PubMed:9305923).INDUCTION By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA).DOMAIN The integrin-binding motif mediates the binding to integrin alpha-5/beta-1 (ITGA5:ITGB1) and integrin alpha-V/beta-3 (ITGAV:ITGB3) and is required for the function in integrin-mediated cell-cell adhesion.DOMAIN The dityrosine basolateral targeting motif mediates localization to the basolateral membrane in polarized cells.PTM N-glycosylated (PubMed:9705349). Contains high-mannose oligosaccharides (PubMed:9705349).SIMILARITY Belongs to the PA-phosphatase related phosphoesterase family. |
| description | recommendedName: fullName evidence="19"Phospholipid phosphatase 3 ecNumber evidence="14"3.1.3.- ecNumber evidence="16 17"3.1.3.4 alternativeName: Lipid phosphate phosphohydrolase 3 alternativeName: PAP2-beta alternativeName: Phosphatidate phosphohydrolase type 2b alternativeName: Phosphatidic acid phosphatase 2b shortName: PAP-2b shortName: PAP2b alternativeName: fullName evidence="18"Vascular endothelial growth factor and type I collagen-inducible protein shortName evidence="18"VCIP |
| geneName | PLPP3 LPP3 PPAP2B |
| identifier | O14495 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Endoplasmic reticulum Glycoprotein Golgi apparatus Hydrolase Lipid metabolism Membrane Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | PLPP3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990914] ENSEMBL:ENSG00000162407 PLPP3 [Homo sapiens] |
| secondaryIdentifier | PLPP3_HUMAN B2R651 D3DQ52 Q5U0F7 Q96GW0 Q99782 |
| sequenceLength | 311 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:76132] PLPP3 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14495 PLPP3 (76131)
