Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:O14494 PLPP1

Class:Id	ReferenceGeneProduct:76105
_chainChangeLog	chain:1-284 added on Fri February 6 2015
_displayName	UniProt:O14494 PLPP1
_timestamp	2025-02-21 19:21:17
chain	chain:1-284
checksum	FC2F00617EE07EB3
comment	FUNCTION Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:10962286, PubMed:17379599, PubMed:9305923, PubMed:9607309, PubMed:9705349). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphateCATALYTIC ACTIVITY 1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dihexadecanoyl-sn-glycerol + phosphateCATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + phosphateCATALYTIC ACTIVITY a monoacyl-sn-glycero-3-phosphate + H2O = a monoacylglycerol + phosphateCATALYTIC ACTIVITY (9Z)-octadecenoyl-sn-glycero-3-phosphate + H2O = (9Z-octadecenoyl)-glycerol + phosphateCATALYTIC ACTIVITY a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphateCATALYTIC ACTIVITY 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z-octadecenoyl)-sn-glycerol + phosphateCATALYTIC ACTIVITY a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + phosphate + H(+)CATALYTIC ACTIVITY sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphateCATALYTIC ACTIVITY an N-acylsphing-4-enine 1-phosphate + H2O = an N-acylsphing-4-enine + phosphateCATALYTIC ACTIVITY N-(octanoyl)-sphing-4-enine-1-phosphate + H2O = N-octanoylsphing-4-enine + phosphateCATALYTIC ACTIVITY N-(9Z-octadecenoyl)-ethanolamine phosphate + H2O = N-(9Z-octadecenoyl) ethanolamine + phosphateCATALYTIC ACTIVITY 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + phosphateACTIVITY REGULATION Magnesium-independent phospholipid phosphatase (PubMed:9305923). Insensitive to N-ethylmaleimide (PubMed:9305923). Inhibited by sphingosine, zinc ions and modestly by propanolol (PubMed:9305923, PubMed:9705349). Inhibited by vanadate (PubMed:10962286).BIOPHYSICOCHEMICAL PROPERTIES Lipid metabolism; phospholipid metabolism.SUBUNIT Forms functional homodimers and homooligomers that are not required for substrate recognition and catalytic activity (By similarity). Can also form heterooligomers with PLPP2 and PLPP3 (By similarity).INTERACTION Additional isoforms seem to exist.TISSUE SPECIFICITY Widely expressed with highest expression found in prostate (PubMed:9305923). Found to be down-regulated in colon adenocarcinomas (PubMed:9570154).TISSUE SPECIFICITY Predominant in kidney, lung, placenta and liver.TISSUE SPECIFICITY Predominant in heart and pancreas.INDUCTION By androgens.PTM N-glycosylated (PubMed:10962286, PubMed:9305923). N-linked sugars are of the complex type. N-glycosylation is not required for the phosphatase activity (By similarity).SIMILARITY Belongs to the PA-phosphatase related phosphoesterase family.CAUTION Some reports could not detect a significant activity with sphingosine 1-phosphate as substrate.
description	recommendedName: fullName evidence="19"Phospholipid phosphatase 1 ecNumber evidence="7 12 13 16 17"3.1.3.- ecNumber evidence="4"3.1.3.106 ecNumber evidence="7 13 16 17"3.1.3.4 ecNumber evidence="4"3.6.1.75 alternativeName: Lipid phosphate phosphohydrolase 1 alternativeName: PAP2-alpha alternativeName: Phosphatidate phosphohydrolase type 2a alternativeName: Phosphatidic acid phosphatase 2a shortName: PAP-2a shortName: PAP2a
geneName	PLPP1 LPP1 PPAP2A
identifier	O14494
isSequenceChanged	FALSE
keyword	Alternative splicing Cell membrane Glycoprotein Hydrolase Lipid metabolism Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	PLPP1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8992667] ENSEMBL:ENSG00000067113 PLPP1 [Homo sapiens]
secondaryIdentifier	PLPP1_HUMAN B7ZKN8 G3XA95 O60457 O60463 Q17RZ4
sequenceLength	284
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:149799] UniProt:O14494-2 PLPP1 [Homo sapiens] [ReferenceIsoform:401219] UniProt:O14494-1 PLPP1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:76106] PLPP1 [plasma membrane] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:O14494 PLPP1 (76105)