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Details on Person Ionizing radiation (IR) induces single-strand breaks i.e. cl...
| Class:Id | Summation:75930 |
|---|---|
| _displayName | Ionizing radiation (IR) induces single-strand breaks i.e. cl... |
| _timestamp | 2015-05-16 06:58:16 |
| created | [InstanceEdit:75904] Matthews, L, 2003-09-07 08:47:00 |
| modified | [InstanceEdit:75992] Matthews, L, 2003-09-10 06:00:00 [InstanceEdit:76259] Matthews, L, 2003-10-06 11:54:00 [InstanceEdit:76323] Matthews, L, 2003-10-07 12:00:00 [InstanceEdit:76530] Matthews, L, 2003-10-08 12:30:00 [InstanceEdit:76610] Matthews, L, 0000-00-00 00:00:00 [InstanceEdit:112268] Matthews, L, 2004-04-15 22:30:00 [InstanceEdit:5686700] Orlic-Milacic, Marija, 2015-04-02 [InstanceEdit:5687907] Orlic-Milacic, Marija, 2015-04-10 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 |
| text | Ionizing radiation (IR) induces single-strand breaks i.e. cleavage of the phosphodiester backbone. When two single-strand breaks occur within approximately 10 base pairs, a DNA double-strand break results. IR-induced DSBs are complex DNA damage lesions, containing base damage and frequently containing 5'-OH groups and 3'-hydroxy or phosphoglycolate groups that must be removed prior to ligation in the final step of NHEJ (Friedberg et al, 1995; Nikjoo et al, 2001; Valerie and Povirk, 2003). The Ku70/80 heterodimer (Walker et al., 2001) binds to the ends of the double-strand break. Ku can translocate inwards from the site of the break in an ATP-independent manner (reviewed in Dynan and Yoo, 1998). |
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No pathways have been reviewed or authored by Ionizing radiation (IR) induces single-strand breaks i.e. cl... (75930)
