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Details on Person Presumably the proteins must be released from the DNA prior ...
| Class:Id | Summation:75929 |
|---|---|
| _displayName | Presumably the proteins must be released from the DNA prior ... |
| _timestamp | 2015-05-16 06:58:45 |
| created | [InstanceEdit:75904] Matthews, L, 2003-09-07 08:47:00 |
| modified | [InstanceEdit:76259] Matthews, L, 2003-10-06 11:54:00 [InstanceEdit:5687450] Orlic-Milacic, Marija, 2015-04-07 [InstanceEdit:5687455] Orlic-Milacic, Marija, 2015-04-07 [InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16 |
| text | Presumably the proteins must be released from the DNA prior to end joining but precisely when this step occurs is not known. Mg-ATP and the protein kinase activity of DNA-PKcs are required for repair of DNA double strand breaks (Kurimasa et al, 1999; Kienker et al, 2000; Baumann and West, 1998). In vitro, DNA-PK undergoes autophosphorylation which correlates with loss of protein kinase activity and disruption of the DNA-PKcs-Ku-DNA complex (Chan and Lees-Miller, 1996; Douglas et al, 2001; 2002; Merkle et al, 2002). Moreover, autophosphorylation of DNA-PKcs is required for NHEJ in vivo (Chan et al, 2002; Ding et |
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No pathways have been reviewed or authored by Presumably the proteins must be released from the DNA prior ... (75929)
