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Details on Person 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate

Class:Id	Reaction:75899
_displayName	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate
_doRelease	TRUE
_timestamp	2016-11-22 17:22:51
authored	[InstanceEdit:76232] Gopinathrao, G, 2003-10-02 00:00:00
catalystActivity	[CatalystActivity:549156] phosphatidate phosphatase activity of LPIN1,2,3 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643205] phosphatidate phosphatase activity of LPIN1,2,3 [endoplasmic reticulum membrane] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
input	[SimpleEntity:76108] 1,2-daG3P [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:549163] Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns [LiteratureReference:549166] Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
modified	[InstanceEdit:76100] Gopinathrao, G, 2003-03-10 00:00:00 [InstanceEdit:76232] Gopinathrao, G, 2003-10-02 00:00:00 [InstanceEdit:76562] Gopinathrao, G, 2003-10-10 10:53:18 [InstanceEdit:77375] Joshi-Tope, G, 2003-10-22 08:20:00 [InstanceEdit:77377] Joshi-Tope, G, 2003-10-23 01:03:03 [InstanceEdit:77453] Gopinathrao, G, 2007-03-20 09:37:59 [InstanceEdit:77576] Gopinathrao, G, 2003-10-31 11:42:51 [InstanceEdit:156873] Joshi-Tope, G, 2004-12-14 02:08:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194431] Schmidt, EE, 2007-03-13 12:34:40 [InstanceEdit:428109] D'Eustachio, P, 2009-07-01 [InstanceEdit:549096] D'Eustachio, P, 2010-03-16 [InstanceEdit:549159] D'Eustachio, P, 2010-03-17 [InstanceEdit:549172] D'Eustachio, P, 2010-03-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8949376] D'Eustachio, Peter, 2016-11-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate Conversion of Phosphatidic Acid to Diacylglycerol
output	[SimpleEntity:76103] DAG [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:75885] 1-acyl LPA is acylated to PA by AGPAT (LPAAT) [Homo sapiens] [Reaction:75886] glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated] [Homo sapiens] [Reaction:549112] G3P is acylated to 1-acyl LPA by AGPAT6 [Homo sapiens] [Reaction:75883] DHRS7B reduces GO3P to HXDG3P [Homo sapiens] [BlackBoxEvent:163748] Transcriptional activation of AGPAT1 by ChREBP:MLX [Homo sapiens] [Reaction:1482656] PA is hydrolysed to 1-acyl LPA by PLA2[1] [Homo sapiens] [Reaction:1482679] PA is hydrolysed to 1-acyl LPA by PLA2G2A [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361564] R-HSA-75899.5
summation	[Summation:76253] Lipin proteins LPIN1, 2, and 3, associated with the endoplas...
(hasEvent)	[Pathway:75109] Triglyceride biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:75900] 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1] [Homo sapiens] [Reaction:549192] 1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2] [Homo sapiens] [Reaction:9977035] NSP2 inhibits DGAT1-mediated conversion of diacylglycerol to triacylglycerol [Homo sapiens]
(replacementInstances)	[_Deleted:428111] Deletion of instance: 76130 [_Deleted:428113] Deletion of instance: 76134 [_Deleted:428114] Deletion of instance: 75898
(updatedInstance)	[_UpdateTracker:9781589] Update Tracker - [Reaction:75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate - v60:[addOutput] [_UpdateTracker:9790695] Update Tracker - [Reaction:75899] 1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate - v33:[add_removeCatalystActivity, add_removeLiteratureReference, modifyText]
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