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Details on Person Conversion of malonyl-CoA and acetyl-CoA to palmitate

Class:Id	Reaction:75872
_displayName	Conversion of malonyl-CoA and acetyl-CoA to palmitate
_doRelease	TRUE
_timestamp	2024-03-19 22:28:35
authored	[InstanceEdit:77382] Joshi-Tope, G, 2003-10-23 17:11:00
catalystActivity	[CatalystActivity:539119] fatty acid synthase activity of FASN dimer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
crossReference	[DatabaseIdentifier:9865850] RHEA:14994
figure	[Figure:77457] /figures/Butyrl_Palmitoyl.jpg
input	[SimpleEntity:76183] Ac-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29508] Mal-CoA [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:200074] Human fatty acid synthase: properties and molecular cloning [LiteratureReference:76569] Structural and functional organization of the animal fatty acid synthase.
modified	[InstanceEdit:75933] Gopinathrao, G, 0000-00-00 00:00:00 [InstanceEdit:75969] Gopinathrao, G, 2003-09-11 11:48:00 [InstanceEdit:76212] Gopinathrao, G, 2003-10-03 00:00:00 [InstanceEdit:76232] Gopinathrao, G, 2003-10-02 00:00:00 [InstanceEdit:76562] Gopinathrao, G, 2003-10-10 10:53:18 [InstanceEdit:77113] Gopinathrao, G, 2003-10-16 18:43:13 [InstanceEdit:77377] Joshi-Tope, G, 2003-10-23 01:03:03 [InstanceEdit:77382] Joshi-Tope, G, 2003-10-23 17:11:00 [InstanceEdit:77453] Gopinathrao, G, 2007-03-20 09:37:59 [InstanceEdit:77456] Gopinathrao, G, 2003-10-28 18:31:48 [InstanceEdit:111311] Gopinathrao, G, 2004-02-12 12:01:08 [InstanceEdit:156873] Joshi-Tope, G, 2004-12-14 02:08:12 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:194432] Schmidt, EE, 2007-03-13 12:36:16 [InstanceEdit:539091] D'Eustachio, P, 2010-03-09 [InstanceEdit:539120] D'Eustachio, P, 2010-03-09 [InstanceEdit:5678228] D'Eustachio, Peter, 2015-02-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19
name	Conversion of malonyl-CoA and acetyl-CoA to palmitate acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH => a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+) acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O
output	[SimpleEntity:3632881] PALM [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[Reaction:200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) [Homo sapiens] [Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA [Homo sapiens] [BlackBoxEvent:163743] Transcriptional activation of ACACA by ChREBP:MLX [Homo sapiens] [Reaction:163756] Formation of fatty acid synthase (FAS) dimer [Homo sapiens] [BlackBoxEvent:163733] Transcriptional activation of FASN monomer gene by ChREBP:MLX [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359228] R-HSA-75872.5
summation	[Summation:77381] Cytosolic fatty acid synthase (FAS) complex catalyzes the re...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785110] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v52:[add_removeOutput] [_UpdateTracker:9790524] Update Tracker - [Reaction:75872] acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O - v33:[add_removeCatalystActivity, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9911031] Update Tracker - [Reaction:75872] Conversion of malonyl-CoA and acetyl-CoA to palmitate - v89:[addLiteratureReference, modifyText]
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