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Details on Person ACLY tetramer transforms CIT to Ac-CoA

Class:Id	Reaction:75848
_displayName	ACLY tetramer transforms CIT to Ac-CoA
_doRelease	TRUE
_timestamp	2024-03-19 22:28:30
authored	[InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00
catalystActivity	[CatalystActivity:76189] ATP citrate synthase activity of ACLY tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:75111] Gopinathrao, G, 2003-09-07 15:00:00
crossReference	[DatabaseIdentifier:9857401] RHEA:21162
edited	[InstanceEdit:8954455] Jassal, Bijay, 2017-01-09
input	[SimpleEntity:76190] CIT [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:200064] Cloning and expression of a human ATP-citrate lyase cDNA [LiteratureReference:8954460] Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth [LiteratureReference:8954454] Cytosolic functions of MORC2 in lipogenesis and adipogenesis [LiteratureReference:9857402] Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle [LiteratureReference:9855260] Regulation and function of the mammalian tricarboxylic acid�cycle [LiteratureReference:9857417] Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan [LiteratureReference:9857415] ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase
modified	[InstanceEdit:75903] Gopinathrao, G, 2003-09-07 00:00:00 [InstanceEdit:76100] Gopinathrao, G, 2003-03-10 00:00:00 [InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00 [InstanceEdit:76206] Gopinathrao, G, 2003-10-03 00:00:00 [InstanceEdit:76562] Gopinathrao, G, 2003-10-10 10:53:18 [InstanceEdit:77374] Joshi-Tope, G, 2003-10-22 19:24:00 [InstanceEdit:77377] Joshi-Tope, G, 2003-10-23 01:03:03 [InstanceEdit:77379] Joshi-Tope, G, 2003-10-23 15:19:00 [InstanceEdit:77453] Gopinathrao, G, 2007-03-20 09:37:59 [InstanceEdit:162611] Gopinathrao, G, 2005-04-01 19:07:46 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:163728] Gopinathrao, G, 2005-05-06 17:09:17 [InstanceEdit:200032] D'Eustachio, P, 2007-07-13 20:48:01 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8954455] Jassal, Bijay, 2017-01-09 [InstanceEdit:8955389] Jassal, Bijay, 2017-01-11 [InstanceEdit:8955390] Jassal, Bijay, 2017-01-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857410] Stephan, Ralf, 2024-01-04 [InstanceEdit:9857416] Stephan, Ralf, 2024-01-04 [InstanceEdit:9865851] D'Eustachio, Peter, 2024-03-19
name	ACLY tetramer transforms CIT to Ac-CoA ATP + citrate + CoA => acetyl-CoA + ADP + oxaloacetate + phosphate Generation of Cytoplasmic Acetyl CoA from Citrate
output	[SimpleEntity:76183] Ac-CoA [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:76213] OA [cytosol] [SimpleEntity:29372] Pi [cytosol]
precedingEvent	[Reaction:75849] SLC25A1 exchanges CIT and MAL [Homo sapiens] [Reaction:70975] CS acetylates OA to citrate [Homo sapiens] [Reaction:372843] SLC25A10 mediates exchange of malate and phosphate [Homo sapiens] [Reaction:198440] SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane [Homo sapiens] [BlackBoxEvent:163770] Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX [Homo sapiens] [Reaction:9856549] MLXIPL:MLX binds ACLY gene promoter [Homo sapiens]
regulatedBy	[PositiveRegulation:8954446] Positive regulation by 'MORC2 [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8954455] Jassal, Bijay, 2017-01-09
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361234] R-HSA-75848.7
summation	[Summation:76210] While fatty acid synthesis from acetyl CoA (Ac-CoA) proceeds...
(hasEvent)	[Pathway:75105] Fatty acyl-CoA biosynthesis [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens]
(precedingEvent)	[Reaction:75851] Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA [Homo sapiens] [Reaction:200555] Formation of Malonyl-CoA from Acetyl-CoA (liver) [Homo sapiens] [Reaction:8848215] ACAT2 condenses 2 Ac-CoA to form ACA-CoA [Homo sapiens] [Reaction:8876889] Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781961] Update Tracker - [Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA - v60:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9792200] Update Tracker - [Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA - v22:[addLiteratureReference] [_UpdateTracker:9864038] Update Tracker - [Reaction:75848] ACLY tetramer transforms CIT to Ac-CoA - v88:[addLiteratureReference, modifyText]
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