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Details on Person Proteasome mediated degradation of Cyclin D1

Class:Id	BlackBoxEvent:75825
_displayName	Proteasome mediated degradation of Cyclin D1
_doRelease	TRUE
_timestamp	2016-11-10 00:56:57
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:68869] Walworth, N, O'Donnell, M, 2003-06-05
edited	[InstanceEdit:177986] Matthews, L, 2006-04-14 06:51:12
input	[Complex:177997] multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:177998] Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis
modified	[InstanceEdit:141123] Matthews, L, 2004-09-01 16:15:00 [InstanceEdit:141127] Matthews, L, 2004-09-02 15:00:00 [InstanceEdit:156850] Joshi-Tope, G, 2004-12-13 19:52:35 [InstanceEdit:158084] Schmidt, EE, 2005-01-18 07:58:46 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:170273] Matthews, L, 2006-01-05 00:26:55 [InstanceEdit:177992] Matthews, L, 2006-04-14 12:59:55 [InstanceEdit:178000] Matthews, L, 2006-04-14 13:06:22 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proteasome mediated degradation of Cyclin D1
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:75824] Ubiquitination of Cyclin D1 [Homo sapiens] [Reaction:75823] Relocalization of nuclearly localized Cyclin D1 to the cytoplasm [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360035] R-HSA-75825.3
summation	[Summation:177994] Phosphorylated Cyclin D1 is degraded during S phase by the 2...
(hasEvent)	[Pathway:75815] Ubiquitin-dependent degradation of Cyclin D [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9764010] Futile Cycle: Proteasome mediated degradation of Cyclin D1
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No pathways have been reviewed or authored by Proteasome mediated degradation of Cyclin D1 (75825)