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Details on Person Ubiquitination of Cyclin D1

Class:IdReaction:75824
_displayNameUbiquitination of Cyclin D1
_doReleaseTRUE
_timestamp2022-02-08 21:35:00
authored[InstanceEdit:177982] Matthews, L, 2006-04-14 06:50:45
catalystActivity[CatalystActivity:69594] ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00
edited[InstanceEdit:177986] Matthews, L, 2006-04-14 06:51:12
input[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:75813] p-T286-CCND1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:212962] Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
modified[InstanceEdit:112170] Matthews, L, 0000-00-00 00:00:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:178120] Matthews, L, 2006-04-15 00:37:52
[InstanceEdit:2656454] D'Eustachio, P, 2012-11-23
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8984052] Varusai, Thawfeek, 2017-04-04
[InstanceEdit:9032176] Orlic-Milacic, Marija, 2017-12-07
[InstanceEdit:9764012] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameUbiquitination of Cyclin D1
negativePrecedingEvent[NegativePrecedingEvent:9764010] Futile Cycle: Proteasome mediated degradation of Cyclin D1
output[Complex:177997] multi-ubiquitinated phospho-(T286) Cyclin D1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358863] R-HSA-75824.6
summation[Summation:178119] Cyclin D is targeted for degradation by multi-ubiquitination...
(hasEvent)[Pathway:75815] Ubiquitin-dependent degradation of Cyclin D [Homo sapiens]
(precedingEvent)[BlackBoxEvent:75825] Proteasome mediated degradation of Cyclin D1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781054] Update Tracker - [Reaction:75824] Ubiquitination of Cyclin D1 - v61:[addLiteratureReference]
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