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Details on Person Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta

Class:Id	Reaction:75820
_displayName	Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
_doRelease	TRUE
_timestamp	2017-12-07 18:59:50
catalystActivity	[CatalystActivity:2022841] protein serine/threonine kinase activity of GSK3B [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00
inferredFrom	[Reaction:182564] Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta [Mus musculus]
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:113844] CDK4:CCND1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:184187] Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1
modified	[InstanceEdit:112170] Matthews, L, 0000-00-00 00:00:00 [InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12 [InstanceEdit:113842] Matthews, L, 2004-06-23 15:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:182560] Matthews, L, 2006-07-10 14:52:59 [InstanceEdit:184189] Matthews, L, 2006-07-26 22:29:58 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9032220] Orlic-Milacic, Marija, 2017-12-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta
output	[SimpleEntity:113582] ADP [nucleoplasm] [Complex:75812] phospho(T286)-Cyclin D1:Cdk4 [nucleoplasm] [Homo sapiens]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359962] R-HSA-75820.4
summation	[Summation:179052] At the beginning of this reaction, 1 molecule of 'Cyclin D1:...
(hasEvent)	[Pathway:75815] Ubiquitin-dependent degradation of Cyclin D [Homo sapiens]
(precedingEvent)	[Reaction:75822] Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779875] Update Tracker - [Reaction:75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - v64:[add_removeCatalystActivity]
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No pathways have been reviewed or authored by Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta (75820)