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Details on Person Phosphorylation of Cdc25C at Ser216 by CHEK2

Class:Id	Reaction:75809
_displayName	Phosphorylation of Cdc25C at Ser216 by CHEK2
_doRelease	TRUE
_timestamp	2022-02-22 12:56:45
authored	[InstanceEdit:212506] Sanchez, Y, 2004-02-10 21:59:11
catalystActivity	[CatalystActivity:75808] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:75804] Matthews, L, 2003-09-01 04:23:00
edited	[InstanceEdit:111978] Matthews, L, 2004-03-22 22:00:00
input	[SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:69741] CDC25C [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:210722] Dual phosphorylation controls Cdc25 phosphatases and mitotic entry [LiteratureReference:8986060] Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
modified	[InstanceEdit:113750] Schmidt, EE, 2004-06-21 07:42:57 [InstanceEdit:156494] Matthews, L, 2004-11-16 23:13:33 [InstanceEdit:157403] Matthews, L, 2004-12-28 18:37:27 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:180188] Matthews, L, 2006-05-16 20:51:49 [InstanceEdit:210720] Matthews, L, 2008-01-15 15:58:39 [InstanceEdit:212505] Matthews, L, 2008-02-12 15:45:05 [InstanceEdit:387142] Matthews, L, 2008-12-01 05:48:41 [InstanceEdit:8861951] Orlic-Milacic, Marija, 2016-02-22 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8986070] Rothfels, Karen, 2017-04-21 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Cdc25C at Ser216 by CHEK2
output	[SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:156496] p-S216-CDC25C [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6798268] TP53 and E2F4 inhibit CDC25C expression [Homo sapiens] [Reaction:6798282] TP53 and E2F4 bind the CDC25C gene [Homo sapiens] [Reaction:5683792] p-T68-CHEK2 autophosphorylates [Homo sapiens] [Reaction:5683774] p-T68-CHEK2 dimerizes [Homo sapiens]
releaseDate	2004-07-06
reviewed	[InstanceEdit:165074] Manfredi, James J
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:210723] Matthews, L, 2008-01-15 13:54:21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358937] R-HSA-75809.6
summation	[Summation:210725] Cdc25C is negatively regulated by phosphorylation on Ser 21...
(hasEvent)	[Pathway:75035] Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9029987] p-S216-CDC25C translocates to the cytosol [Homo sapiens]
(replacementInstances)	[_Deleted:732467] Deletion of instance: 75014
(updatedInstance)	[_UpdateTracker:9781268] Update Tracker - [Reaction:75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9791672] Update Tracker - [Reaction:75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - v27:[add_removeInput] [_UpdateTracker:9792062] Update Tracker - [Reaction:75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - v24:[addLiteratureReference, addSummation]
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