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Details on Person UniProt:Q9NYR8 RDH8
| Class:Id | ReferenceGeneProduct:75381 |
|---|---|
| _chainChangeLog | chain:1-311 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NYR8 RDH8 |
| _timestamp | 2026-02-20 22:26:08 |
| chain | chain:1-311 |
| checksum | D62416D1F0377ECE |
| comment | FUNCTION Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).CATALYTIC ACTIVITY all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)SUBCELLULAR LOCATION Detected in photoreceptor outer segments in the retina (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| created | [InstanceEdit:75321] Schmidt, EE, 2003-09-01 06:01:22 |
| description | recommendedName: Retinol dehydrogenase 8 ecNumber evidence="2"1.1.1.300 alternativeName: Photoreceptor outer segment all-trans retinol dehydrogenase alternativeName: Short chain dehydrogenase/reductase family 28C member 2 |
| geneName | RDH8 PRRDH SDR28C2 |
| identifier | Q9NYR8 |
| isSequenceChanged | FALSE |
| keyword | Lipid metabolism Membrane NADP Oxidoreductase Proteomics identification Reference proteome Sensory transduction Stargardt disease Transmembrane Transmembrane helix Vision |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RDH8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989763] ENSEMBL:ENSG00000080511 RDH8 [Homo sapiens] |
| secondaryIdentifier | RDH8_HUMAN Q9H838 |
| sequenceLength | 311 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:75382] RDH8 [photoreceptor outer segment membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9NYR8 RDH8 (75381)
