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Details on Person UniProt:Q92698 RAD54L
| Class:Id | ReferenceGeneProduct:75249 |
|---|---|
| _chainChangeLog | chain:1-747 added on Fri February 6 2015 |
| _displayName | UniProt:Q92698 RAD54L |
| _timestamp | 2026-02-20 22:37:17 |
| chain | chain:1-747 |
| checksum | 718100974CA6687B |
| comment | FUNCTION Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11459989, PubMed:12205100, PubMed:24798879, PubMed:27264870, PubMed:32457312, PubMed:9774452). Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity).CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)BIOPHYSICOCHEMICAL PROPERTIES Homohexamer (By similarity). Interacts (via N-terminus) with RAD51; RAD51 nucleoprotein filament stimulate RAD54L ATPase activity (PubMed:9321665, PubMed:11884632). Interacts with NAP1L1 (PubMed:24798879). Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex formation (PubMed:32457312).INTERACTION Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle.PTM Acetylated. Acetylation promotes interaction with BRD9, and subsequently with RAD54, which is essential for homologous recombination (HR).PTM Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in G2 phase allows efficient removal of RAD51 filaments from DNA.SIMILARITY Belongs to the SNF2/RAD54 helicase family. |
| description | recommendedName: fullName evidence="19"DNA repair and recombination protein RAD54-like ecNumber evidence="9 16"3.6.4.- alternativeName: RAD54 homolog shortName: hHR54 shortName: hRAD54 |
| geneName | RAD54L RAD54A |
| identifier | Q92698 |
| isSequenceChanged | FALSE |
| keyword | Acetylation DNA damage DNA repair DNA-binding Hydrolase Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | RAD54L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999110] ENSEMBL:ENSG00000085999 RAD54L [Homo sapiens] |
| secondaryIdentifier | RAD54_HUMAN Q5TE31 Q6IUY3 |
| sequenceLength | 747 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:75250] RAD54L [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q92698 RAD54L (75249)
